(E)-N-<3--N'-methyl>aminopropyl>-4-(4-methylthiophenyl)-3-butenamide

Base Information

• Chemical Name: (E)-N-<3--N'-methyl>aminopropyl>-4-(4-methylthiophenyl)-3-butenamide
• CAS No.: 127405-68-9
• Molecular Formula: C₂₅H₃₄N₂O₃S
• Molecular Weight: 442.623

Synonyms:

Chemical Property of (E)-N-<3--N'-methyl>aminopropyl>-4-(4-methylthiophenyl)-3-butenamide

Chemical Property:

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Technology Process of (E)-N-<3--N'-methyl>aminopropyl>-4-(4-methylthiophenyl)-3-butenamide

There total 4 articles about (E)-N-<3--N'-methyl>aminopropyl>-4-(4-methylthiophenyl)-3-butenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-methylhomoveratrylamine (3490-06-0) → (E)-N-<3--N'-methyl>aminopropyl>-4-(4-methylthiophenyl)-3-butenamide (127405-68-9)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol / 3 h / Ambient temperature

2: H₂, aq. HCl / PtO₂ / ethanol / 2280 Torr / Ambient temperature

3: DCC, 1-hydroxybenzotriazole / acetonitrile / 0.5 h / 70 °C

With hydrogenchloride; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; platinum(IV) oxide; In ethanol; acetonitrile;

DOI:10.1248/cpb.40.2735

Reference yield:

3-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]propanenitrile (916993-73-2) → (E)-N-<3--N'-methyl>aminopropyl>-4-(4-methylthiophenyl)-3-butenamide (127405-68-9)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂, aq. HCl / PtO₂ / ethanol / 2280 Torr / Ambient temperature

2: DCC, 1-hydroxybenzotriazole / acetonitrile / 0.5 h / 70 °C

With hydrogenchloride; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; platinum(IV) oxide; In ethanol; acetonitrile;

DOI:10.1248/cpb.40.2735

Reference yield:

1-[N-methyl-N-(2(3,4-dimethoxy-phenyl)-ethyl)-amino]-3-aminopropane (55982-99-5) + (E)-4-(4-(methylthio)phenyl)but-3-enoic acid (127404-68-6) → (E)-N-<3--N'-methyl>aminopropyl>-4-(4-methylthiophenyl)-3-butenamide (127405-68-9)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In acetonitrile; at 70 ℃; for 0.5h;

DOI:10.1248/cpb.40.2735

upstream raw materials:

1-[N-methyl-N-(2(3,4-dimethoxy-phenyl)-ethyl)-amino]-3-aminopropane

(E)-4-(4-(methylthio)phenyl)but-3-enoic acid

N-methylhomoveratrylamine

3-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]propanenitrile

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