(S)-2-Amino-4-methyl-pentanoic acid [(R)-1-carbamoyl-2-(4-methoxy-benzylsulfanyl)-ethyl]-amide; compound with trifluoro-acetic acid

Base Information

• Chemical Name: (S)-2-Amino-4-methyl-pentanoic acid [(R)-1-carbamoyl-2-(4-methoxy-benzylsulfanyl)-ethyl]-amide; compound with trifluoro-acetic acid
• CAS No.: 97721-60-3
• Molecular Formula: C₂HF₃O₂*C₁₇H₂₇N₃O₃S
• Molecular Weight: 467.51
• Mol file: 97721-60-3.mol

Synonyms:

Chemical Property of (S)-2-Amino-4-methyl-pentanoic acid [(R)-1-carbamoyl-2-(4-methoxy-benzylsulfanyl)-ethyl]-amide; compound with trifluoro-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-Amino-4-methyl-pentanoic acid [(R)-1-carbamoyl-2-(4-methoxy-benzylsulfanyl)-ethyl]-amide; compound with trifluoro-acetic acid

There total 4 articles about (S)-2-Amino-4-methyl-pentanoic acid [(R)-1-carbamoyl-2-(4-methoxy-benzylsulfanyl)-ethyl]-amide; compound with trifluoro-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) → (S)-2-Amino-4-methyl-pentanoic acid [(R)-1-carbamoyl-2-(4-methoxy-benzylsulfanyl)-ethyl]-amide; compound with trifluoro-acetic acid (97721-60-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 66 percent / dicyclohexylcarbodiimide (DCC), N-methylmorpholine (NMM) / CH₂Cl₂ / 1.) 0 deg C, 8 h, 2.) RT, 12 h

2: 69 percent / NH₃ / methanol / 72 h / Ambient temperature

3: CH₂Cl₂ / 0.75 h / 20 °C

With 4-methyl-morpholine; ammonia; dicyclohexyl-carbodiimide; In methanol; dichloromethane;

DOI:10.1021/jm00148a029

Reference yield:

S-<(4-methoxyphenyl)methyl>-L-cysteine methyl ester hydrochloride (71449-22-4) → (S)-2-Amino-4-methyl-pentanoic acid [(R)-1-carbamoyl-2-(4-methoxy-benzylsulfanyl)-ethyl]-amide; compound with trifluoro-acetic acid (97721-60-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 66 percent / dicyclohexylcarbodiimide (DCC), N-methylmorpholine (NMM) / CH₂Cl₂ / 1.) 0 deg C, 8 h, 2.) RT, 12 h

2: 69 percent / NH₃ / methanol / 72 h / Ambient temperature

3: CH₂Cl₂ / 0.75 h / 20 °C

With 4-methyl-morpholine; ammonia; dicyclohexyl-carbodiimide; In methanol; dichloromethane;

DOI:10.1021/jm00148a029

Reference yield:

N-t-Boc-Leu-(p-MeOBzl)Cys-OMe (97721-57-8) → (S)-2-Amino-4-methyl-pentanoic acid [(R)-1-carbamoyl-2-(4-methoxy-benzylsulfanyl)-ethyl]-amide; compound with trifluoro-acetic acid (97721-60-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / NH₃ / methanol / 72 h / Ambient temperature

2: CH₂Cl₂ / 0.75 h / 20 °C

With ammonia; In methanol; dichloromethane;

DOI:10.1021/jm00148a029

upstream raw materials:

N-t-Boc-Leu-(p-MeOBzl)Cys-NH₂

trifluoroacetic acid

N-tert-butoxycarbonyl-L-leucine

S-<(4-methoxyphenyl)methyl>-L-cysteine methyl ester hydrochloride

Downstream raw materials:

N-t-Boc-Gln-Phe-Phe-Gly-Leu-(p-MeOBzl)Cys-NH₂

H-Cys-Gln-Phe-Phe-Gly-Leu-Cys-NH₂

C₅₂H₆₇N₉O₉S₂