Phosphoric acid 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester (2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Base Information

• Chemical Name: Phosphoric acid 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester (2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester
• CAS No.: 104766-14-5
• Molecular Formula: C₃₈H₃₅ClN₃O₈P
• Molecular Weight: 728.138
• Mol file: 104766-14-5.mol

Synonyms:

Chemical Property of Phosphoric acid 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester (2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphoric acid 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester (2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

There total 6 articles about Phosphoric acid 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester (2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester (87007-23-6) → Phosphoric acid 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester (2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester (104766-14-5)

Guidance literature:

With benzenesulfonic acid; In methanol; chloroform;

DOI:10.1016/S0040-4039(00)88013-2

Reference yield:

4-tritylphenol (978-86-9) → Phosphoric acid 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester (2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester (104766-14-5)

Guidance literature:

Multi-step reaction with 6 steps

1: N-chloroacetamide/HCl / H₂O; dioxane

2: POCl₃,ethyl-1 methyl-2 chloro-5 imidazole

3: pyridine

4: 65 percent / pyridine / 1 h / Ambient temperature

5: 80 percent / mesitylsulfonyl-1 nitro-3 triazole-1,2,4 / pyridine / 1 h / Ambient temperature

6: acide benzenesulfonique a 2percent / CHCl₃; methanol

With pyridine; hydrogenchloride; N-chloroacetamide; POCl₃,ethyl-1 methyl-2 chloro-5 imidazole; 1-(mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole; benzenesulfonic acid; trichlorophosphate; In 1,4-dioxane; pyridine; methanol; chloroform; water;

DOI:10.1016/S0040-4039(00)88013-2

Reference yield:

2-chloro-4-trityl-phenol (859820-69-2) → Phosphoric acid 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester (2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester (104766-14-5)

Guidance literature:

Multi-step reaction with 5 steps

1: POCl₃,ethyl-1 methyl-2 chloro-5 imidazole

2: pyridine

3: 65 percent / pyridine / 1 h / Ambient temperature

4: 80 percent / mesitylsulfonyl-1 nitro-3 triazole-1,2,4 / pyridine / 1 h / Ambient temperature

5: acide benzenesulfonique a 2percent / CHCl₃; methanol

With pyridine; POCl₃,ethyl-1 methyl-2 chloro-5 imidazole; 1-(mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole; benzenesulfonic acid; trichlorophosphate; In pyridine; methanol; chloroform;

DOI:10.1016/S0040-4039(00)88013-2

upstream raw materials:

Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester

4-tritylphenol

2-chloro-4-trityl-phenol

Phosphoric acid 2-chloro-4-trityl-phenyl ester bis-(2-cyano-ethyl) ester