C₂₆H₂₆N₈O₂

Base Information

• Chemical Name: C₂₆H₂₆N₈O₂
• CAS No.: 1207366-48-0
• Molecular Formula: C₂₆H₂₆N₈O₂
• Molecular Weight: 482.545
• Mol file: 1207366-48-0.mol

Synonyms:

Chemical Property of C₂₆H₂₆N₈O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₂₆N₈O₂

There total 9 articles about C₂₆H₂₆N₈O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

6-(benzyloxy)-N-(4-(4-morpholino-7-(pyrimidin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)pyridin-2-amine (1415797-57-7) → C26H26N8O2 (1207366-48-0)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; acetic acid; In tetrahydrofuran;

DOI:10.1021/ml3003132

Reference yield:

2,6-Dibromopyridine (626-05-1) → C26H26N8O2 (1207366-48-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 0 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate / toluene / 0.33 h / Microwave irradiation; Heating; Inert atmosphere

3.1: 5%-palladium/activated carbon; hydrogen; acetic acid / tetrahydrofuran

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 5%-palladium/activated carbon; hydrogen; sodium hydride; acetic acid; sodium t-butanolate; DavePhos; In tetrahydrofuran; toluene; mineral oil;

DOI:10.1021/ml3003132

Reference yield:

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nitrobenzene (171364-83-3) → C26H26N8O2 (1207366-48-0)

Guidance literature:

Multi-step reaction with 6 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium acetate / acetonitrile; water / 0.25 h / Microwave irradiation; Heating; Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / Microwave irradiation; Heating; Inert atmosphere

4: tin(II) chloride dihdyrate / ethanol / 1 h / Inert atmosphere; Reflux

5: DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate / toluene / 0.33 h / Microwave irradiation; Heating; Inert atmosphere

6: 5%-palladium/activated carbon; hydrogen; acetic acid / tetrahydrofuran

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tin(II) chloride dihdyrate; 5%-palladium/activated carbon; hydrogen; potassium acetate; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium t-butanolate; DavePhos; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; 1: |Suzuki Coupling;

DOI:10.1021/ml3003132

upstream raw materials:

tert-butyl 2-chloro-4-morpholino-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate

2,6-Dibromopyridine

4-(4-morpholino-7-(pyrimidin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)aniline

2-(benzyloxy)-6-bromopyridine