3,5-difluoro-4-iodobenzaldehyde

Base Information

• Chemical Name: 3,5-difluoro-4-iodobenzaldehyde
• CAS No.: 357166-64-4
• Molecular Formula: C₇H₃F₂IO
• Molecular Weight: 268.002
• Mol file: 357166-64-4.mol

Synonyms:

Chemical Property of 3,5-difluoro-4-iodobenzaldehyde

Chemical Property:

• Boiling Point: 256.9±40.0 °C(Predicted)
• Density: 2.036±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

3,5-Difluoro-4-iodobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-difluoro-4-iodobenzaldehyde

There total 2 articles about 3,5-difluoro-4-iodobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3,5-difluoro-4-iodobenzonitrile → 3,5-difluoro-4-iodobenzaldehyde (357166-64-4)

Guidance literature:

3,5-difluoro-4-iodobenzonitrile; With diisobutylaluminium hydride; In dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere;

With hydrogenchloride; water;

DOI:10.1007/s00259-019-04357-w

Reference yield:

3,5-difluorobenzonitrile (64248-63-1) → 3,5-difluoro-4-iodobenzaldehyde (357166-64-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 1 h / -76 °C / Inert atmosphere

1.2: -60 - 20 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / dichloromethane / 1 h / -10 - 20 °C / Inert atmosphere

With n-butyllithium; diisobutylaluminium hydride; diisopropylamine; In tetrahydrofuran; hexane; dichloromethane;

Reference yield:

3,5-difluoro-4-iodobenzaldehyde (357166-64-4) → [2,6-difluoro-4-(2-fluoro-4-(trans-propylcyclohexyl)phenyl)phenyloxy]-[3,5-difluoro-4-(4-trifluoromethoxyphenyl)phenyl]methane

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tetrahydroborate / ethanol; water / 1 h / 20 °C / Cooling with ice

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 8 h / 100 °C / Inert atmosphere

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran; water / 1 h / 20 °C / Inert atmosphere; Cooling with ice

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; di-isopropyl azodicarboxylate; potassium carbonate; triphenylphosphine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

upstream raw materials:

3,5-difluorobenzonitrile