2,2-Dimethyl-propionic acid (2R,3S,5R)-3-[{3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2,2-dicyano-propoxy}-(2-methoxy-ethoxy)-phosphoryloxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (2R,3S,5R)-3-[{3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2,2-dicyano-propoxy}-(2-methoxy-ethoxy)-phosphoryloxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester
CAS No.:357610-48-1
Molecular Formula:C₄₄H₅₁N₄O₁₃P
Molecular Weight:874.882
Hs Code.:

2,2-Dimethyl-propionic acid (2R,3S,5R)-3-[{3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2,2-dicyano-propoxy}-(2-methoxy-ethoxy)-phosphoryloxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (2R,3S,5R)-3-[{3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2,2-dicyano-propoxy}-(2-methoxy-ethoxy)-phosphoryloxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

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Technology Process of 2,2-Dimethyl-propionic acid (2R,3S,5R)-3-[{3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2,2-dicyano-propoxy}-(2-methoxy-ethoxy)-phosphoryloxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

There total 3 articles about 2,2-Dimethyl-propionic acid (2R,3S,5R)-3-[{3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2,2-dicyano-propoxy}-(2-methoxy-ethoxy)-phosphoryloxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 86850-86-4
2,2-bis(hydroxymethyl)malononitrile

: 357610-48-1
2,2-Dimethyl-propionic acid (2R,3S,5R)-3-[{3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2,2-dicyano-propoxy}-(2-methoxy-ethoxy)-phosphoryloxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / dioxane

2.1: phosphoryl tris(triazolide) / acetonitrile

2.2: acetonitrile

2.3: acetonitrile

With pyridine; tri(1H-1,2,4-triazol-1-yl)phosphine oxide; In 1,4-dioxane; acetonitrile;
DOI:10.1039/b101754n

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 357610-48-1
2,2-Dimethyl-propionic acid (2R,3S,5R)-3-[{3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2,2-dicyano-propoxy}-(2-methoxy-ethoxy)-phosphoryloxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / dioxane

2.1: phosphoryl tris(triazolide) / acetonitrile

2.2: acetonitrile

2.3: acetonitrile

With pyridine; tri(1H-1,2,4-triazol-1-yl)phosphine oxide; In 1,4-dioxane; acetonitrile;
DOI:10.1039/b101754n

Reference yield:

: 109-86-4,95507-80-5
2-methoxy-ethanol

: 40733-25-3
2'-deoxy-5'-O-pivaloylthymidine

: 357610-44-7
2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-hydroxymethyl-malononitrile

: 357610-48-1
2,2-Dimethyl-propionic acid (2R,3S,5R)-3-[{3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2,2-dicyano-propoxy}-(2-methoxy-ethoxy)-phosphoryloxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-hydroxymethyl-malononitrile; With tri(1H-1,2,4-triazol-1-yl)phosphine oxide; In acetonitrile;

2'-deoxy-5'-O-pivaloylthymidine; In acetonitrile;

2-methoxy-ethanol; In acetonitrile;
DOI:10.1039/b101754n