(1R)-N-acetoxy-N-benzyl-N-[2-(tert-butyldiphenylsilyloxy)-1-(2,2-dimethyl-[1,3]dioxolan-4(R)-yl)-1-methylethyl]amine

Base Information

• Chemical Name: (1R)-N-acetoxy-N-benzyl-N-[2-(tert-butyldiphenylsilyloxy)-1-(2,2-dimethyl-[1,3]dioxolan-4(R)-yl)-1-methylethyl]amine
• CAS No.: 857293-94-8
• Molecular Formula: C₃₃H₄₃NO₅Si
• Molecular Weight: 561.794
• Mol file: 857293-94-8.mol

Synonyms:

Chemical Property of (1R)-N-acetoxy-N-benzyl-N-[2-(tert-butyldiphenylsilyloxy)-1-(2,2-dimethyl-[1,3]dioxolan-4(R)-yl)-1-methylethyl]amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R)-N-acetoxy-N-benzyl-N-[2-(tert-butyldiphenylsilyloxy)-1-(2,2-dimethyl-[1,3]dioxolan-4(R)-yl)-1-methylethyl]amine

There total 2 articles about (1R)-N-acetoxy-N-benzyl-N-[2-(tert-butyldiphenylsilyloxy)-1-(2,2-dimethyl-[1,3]dioxolan-4(R)-yl)-1-methylethyl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic anhydride (108-24-7) + N-benzyl-N-[2-(tert-butyldiphenylsilyloxy)-1-(2,2-dimethyl-[1,3]dioxolan-4(R)-yl)-1-methylethyl]hydroxylamine → (1S)-N-acetoxy-N-benzyl-N-[2-(tert-butyldiphenylsilyloxy)-1-(2,2-dimethyl-[1,3]dioxolan-4(R)-yl)-1-methylethyl]amine + (1R)-N-acetoxy-N-benzyl-N-[2-(tert-butyldiphenylsilyloxy)-1-(2,2-dimethyl-[1,3]dioxolan-4(R)-yl)-1-methylethyl]amine (857293-94-8)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1055/s-2002-25358

Reference yield:

acetic anhydride (108-24-7) + (1R)-N-benzyl-N-[2-(tert-butyldiphenylsilyloxy)-1-(2,2-dimethyl-[1,3]dioxolan-4(R)-yl)-1-methylethyl]hydroxylamine (857293-91-5) → (1R)-N-acetoxy-N-benzyl-N-[2-(tert-butyldiphenylsilyloxy)-1-(2,2-dimethyl-[1,3]dioxolan-4(R)-yl)-1-methylethyl]amine (857293-94-8)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1055/s-2002-25358

Reference yield:

(1R)-N-acetoxy-N-benzyl-N-[2-(tert-butyldiphenylsilyloxy)-1-(2,2-dimethyl-[1,3]dioxolan-4(R)-yl)-1-methylethyl]amine (857293-94-8) → C29H35NO4Si

Guidance literature:

With periodic acid; In diethyl ether; at 20 ℃; for 4h;

DOI:10.1016/j.tetasy.2005.03.013

upstream raw materials:

acetic anhydride

(1R)-N-benzyl-N-[2-(tert-butyldiphenylsilyloxy)-1-(2,2-dimethyl-[1,3]dioxolan-4(R)-yl)-1-methylethyl]hydroxylamine

Downstream raw materials:

C₁₄H₁₉NO₅

methyl (2R)-2-(N-acetoxy-N-benzylamino)-3-(tert-butyldiphenylsilyloxy)-2-methylpropionate