(S)-2-((S)-2-{[(2R,3S,4R,5R)-3,4-Bis-benzyloxy-5-(tert-butoxycarbonylamino-methyl)-tetrahydro-furan-2-carbonyl]-amino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid

Base Information

Chemical Name:(S)-2-((S)-2-{[(2R,3S,4R,5R)-3,4-Bis-benzyloxy-5-(tert-butoxycarbonylamino-methyl)-tetrahydro-furan-2-carbonyl]-amino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid
CAS No.:443123-72-6
Molecular Formula:C₄₀H₅₁N₃O₉
Molecular Weight:717.86
Hs Code.:

(S)-2-((S)-2-{[(2R,3S,4R,5R)-3,4-Bis-benzyloxy-5-(tert-butoxycarbonylamino-methyl)-tetrahydro-furan-2-carbonyl]-amino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid

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Chemical Property of (S)-2-((S)-2-{[(2R,3S,4R,5R)-3,4-Bis-benzyloxy-5-(tert-butoxycarbonylamino-methyl)-tetrahydro-furan-2-carbonyl]-amino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid

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Technology Process of (S)-2-((S)-2-{[(2R,3S,4R,5R)-3,4-Bis-benzyloxy-5-(tert-butoxycarbonylamino-methyl)-tetrahydro-furan-2-carbonyl]-amino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid

There total 1 articles about (S)-2-((S)-2-{[(2R,3S,4R,5R)-3,4-Bis-benzyloxy-5-(tert-butoxycarbonylamino-methyl)-tetrahydro-furan-2-carbonyl]-amino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 303764-46-7
Boc-Gaa(Bn₂)-Phe-Leu-OMe

: 443123-72-6
(S)-2-((S)-2-{[(2R,3S,4R,5R)-3,4-Bis-benzyloxy-5-(tert-butoxycarbonylamino-methyl)-tetrahydro-furan-2-carbonyl]-amino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid

Guidance literature:: With lithium hydroxide; water; In tetrahydrofuran; methanol; at 0 ℃; for 2h;
DOI:10.1016/S0040-4020(02)00158-8

Reference yield:

: 443123-72-6
(S)-2-((S)-2-{[(2R,3S,4R,5R)-3,4-Bis-benzyloxy-5-(tert-butoxycarbonylamino-methyl)-tetrahydro-furan-2-carbonyl]-amino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid

: C₄₈H₇₀N₆O₁₅

Guidance literature:: Multi-step reaction with 2 steps

1: HOBt; EDCI; DIPEA / CH₂Cl₂ / 8 h / 20 °C

2: 123 mg / H₂ / 20 percent Pd(OH)2 on C / methanol / 12 h / 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium hydroxide - carbon; In methanol; dichloromethane;
DOI:10.1016/S0040-4020(02)00158-8

Reference yield:

: TFA*H₂N-Gaa(Bn₂)-Phe-Leu-OMe

: 443123-72-6
(S)-2-((S)-2-{[(2R,3S,4R,5R)-3,4-Bis-benzyloxy-5-(tert-butoxycarbonylamino-methyl)-tetrahydro-furan-2-carbonyl]-amino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid

: 443123-75-9
C₇₆H₉₄N₆O₁₅

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 8h;
DOI:10.1016/S0040-4020(02)00158-8