Technology Process of 4-(trichloromethylcarbonylamino)-1,2,3,4-tetrahydro-2-(p-toluenesulfonyl)benzo[f]isoquinoline-5,8-dione
There total 8 articles about 4-(trichloromethylcarbonylamino)-1,2,3,4-tetrahydro-2-(p-toluenesulfonyl)benzo[f]isoquinoline-5,8-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
manganese(IV) oxide;
In
toluene;
at 115 ℃;
for 2h;
Inert atmosphere;
Microwave irradiation;
DOI:10.1021/jo401182r
- Guidance literature:
-
Multi-step reaction with 2 steps
1: toluene / 72 h / 115 °C / Inert atmosphere
2: manganese(IV) oxide / toluene / 2 h / 115 °C / Inert atmosphere; Microwave irradiation
With
manganese(IV) oxide;
In
toluene;
1: |Diels-Alder Cycloaddition;
DOI:10.1021/jo401182r
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: dimethyl sulfoxide; triethylamine / dichloromethane / -78 - 20 °C / Inert atmosphere
1.2: 3.5 h / -78 - 20 °C / Inert atmosphere
2.1: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 1 h / Inert atmosphere
2.2: 20 °C / Inert atmosphere
3.1: diisobutylaluminium hydride / diethyl ether / -78 - 20 °C / Inert atmosphere
4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
5.1: potassium carbonate / toluene / 24 h / 140 °C / Inert atmosphere; Sealed tube
6.1: Hoveyda-Grubbs catalyst second generation / 24 h / 90 °C / Inert atmosphere
7.1: toluene / 72 h / 115 °C / Inert atmosphere
8.1: manganese(IV) oxide / toluene / 2 h / 115 °C / Inert atmosphere; Microwave irradiation
With
manganese(IV) oxide; Hoveyda-Grubbs catalyst second generation; diisobutylaluminium hydride; potassium carbonate; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium chloride;
In
diethyl ether; dichloromethane; toluene; acetonitrile;
1.1: |Swern Oxidation / 1.2: |Swern Oxidation / 2.1: |Horner-Wadsworth-Emmons Olefination / 2.2: |Horner-Wadsworth-Emmons Olefination / 7.1: |Diels-Alder Cycloaddition;
DOI:10.1021/jo401182r
