Technology Process of methyl 2-(1-benzyl-2,2-dioxido-1,3-dihydrobenzo[c]isothiazol-6-yl)acetate
There total 10 articles about methyl 2-(1-benzyl-2,2-dioxido-1,3-dihydrobenzo[c]isothiazol-6-yl)acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 15 h / 20 - 100 °C
2.1: tetrabutylammomium bromide; sodium sulfite / water; methanol / 3 h / 20 - 100 °C
3.1: hydrogen; palladium 10% on activated carbon / methanol / 12 h / 3102.97 Torr / Inert atmosphere
4.1: trichlorophosphate / 20 - 150 °C
5.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C
5.2: 2 h / 0 - 20 °C
6.1: sodium hydroxide / water; methanol / 2 h / 0 - 50 °C
6.2: 0 °C / pH 2
7.1: thionyl chloride / 20 °C / Inert atmosphere
8.1: ethanol; tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere
9.1: triethylamine; silver benzoate / 1 h / 20 - 50 °C
With
N-Bromosuccinimide; thionyl chloride; palladium 10% on activated carbon; tetrabutylammomium bromide; hydrogen; silver benzoate; potassium carbonate; triethylamine; sodium hydroxide; sodium sulfite; trichlorophosphate; dibenzoyl peroxide;
In
tetrahydrofuran; methanol; tetrachloromethane; ethanol; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C
1.2: 2 h / 0 - 20 °C
2.1: sodium hydroxide / water; methanol / 2 h / 0 - 50 °C
2.2: 0 °C / pH 2
3.1: thionyl chloride / 20 °C / Inert atmosphere
4.1: ethanol; tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere
5.1: triethylamine; silver benzoate / 1 h / 20 - 50 °C
With
thionyl chloride; silver benzoate; potassium carbonate; triethylamine; sodium hydroxide;
In
tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: hydrogen; palladium 10% on activated carbon / methanol / 12 h / 3102.97 Torr / Inert atmosphere
2.1: trichlorophosphate / 20 - 150 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C
3.2: 2 h / 0 - 20 °C
4.1: sodium hydroxide / water; methanol / 2 h / 0 - 50 °C
4.2: 0 °C / pH 2
5.1: thionyl chloride / 20 °C / Inert atmosphere
6.1: ethanol; tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere
7.1: triethylamine; silver benzoate / 1 h / 20 - 50 °C
With
thionyl chloride; palladium 10% on activated carbon; hydrogen; silver benzoate; potassium carbonate; triethylamine; sodium hydroxide; trichlorophosphate;
In
tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;
