2-(3-((5-cyclopropyl-3-(2-(difluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid

Base Information

Chemical Name:2-(3-((5-cyclopropyl-3-(2-(difluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid
CAS No.:1383816-46-3
Molecular Formula:C₂₉H₂₆F₃N₃O₅S
Molecular Weight:585.604
Hs Code.:

2-(3-((5-cyclopropyl-3-(2-(difluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid

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Chemical Property of 2-(3-((5-cyclopropyl-3-(2-(difluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid

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Technology Process of 2-(3-((5-cyclopropyl-3-(2-(difluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid

There total 11 articles about 2-(3-((5-cyclopropyl-3-(2-(difluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383816-45-2
methyl 2-(3-((5-cyclopropyl-3-(2-(difluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylate

: 1383816-46-3
2-(3-((5-cyclopropyl-3-(2-(difluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; methanol; water; at 70 ℃; for 1h;
DOI:10.1021/acs.jmedchem.7b00907

Reference yield:

: C₁₄H₁₃F₂NO₃

: 1383816-46-3
2-(3-((5-cyclopropyl-3-(2-(difluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine / dichloromethane

1.2: 1 h

2.1: potassium tert-butylate; 18-crown-6 ether / tetrahydrofuran / 1 h / Inert atmosphere

2.2: Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.1: caesium carbonate / N,N-dimethyl acetamide / 1 h / 60 °C

5.1: potassium hydroxide / water; tetrahydrofuran; methanol / 1 h / 70 °C

With 18-crown-6 ether; potassium tert-butylate; caesium carbonate; triphenylphosphine; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; water;
DOI:10.1021/acs.jmedchem.7b00907

Reference yield:

: C₁₄H₁₂BrF₂NO₂

: 1383816-46-3
2-(3-((5-cyclopropyl-3-(2-(difluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate; 18-crown-6 ether / tetrahydrofuran / 1 h / Inert atmosphere

1.2: Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.1: caesium carbonate / N,N-dimethyl acetamide / 1 h / 60 °C

4.1: potassium hydroxide / water; tetrahydrofuran; methanol / 1 h / 70 °C

With 18-crown-6 ether; potassium tert-butylate; caesium carbonate; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; water;
DOI:10.1021/acs.jmedchem.7b00907