Acetamide, 2-(4-chlorophenoxy)-N-hydroxy-

Base Information

• Chemical Name: Acetamide, 2-(4-chlorophenoxy)-N-hydroxy-
• CAS No.: 13359-17-6
• Molecular Formula: C8H8ClNO3
• Molecular Weight: 201.609
• DSSTox Substance ID: DTXSID10457945
• Nikkaji Number: J1.772.176C
• Wikidata: Q82281033
• ChEMBL ID: CHEMBL4248008
• Mol file: 13359-17-6.mol

Synonyms:CHEMBL4248008;2-(4-chlorophenoxy)-n-hydroxyacetamide;Acetamide, 2-(4-chlorophenoxy)-N-hydroxy-;13359-17-6;SCHEMBL1255820;DTXSID10457945;BDBM50462872;AKOS000173872;N-hydroxy-2-(4chlorophenoxy)acetamide;2-(4-Chlorophenoxy)acetohydroxamic acid

Chemical Property of Acetamide, 2-(4-chlorophenoxy)-N-hydroxy-

Chemical Property:

• XLogP3: 1.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 201.0192708
• Heavy Atom Count: 13
• Complexity: 169

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1OCC(=O)NO)Cl

Technology Process of Acetamide, 2-(4-chlorophenoxy)-N-hydroxy-

There total 4 articles about Acetamide, 2-(4-chlorophenoxy)-N-hydroxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

ethyl p-chlorophenoxyacetate (14426-42-7) → 2-(4-chlorophenoxy)acetohydroxamic acid (13359-17-6)

Guidance literature:

With hydroxylamine hydrochloride; sodium methylate; In methanol; at 20 ℃;

DOI:10.1016/j.bmc.2018.07.003

Reference yield: 58.0%

(4-chloro-phenoxy)-acetic acid methyl ester (4841-22-9) → 2-(4-chlorophenoxy)acetohydroxamic acid (13359-17-6)

Guidance literature:

With hydroxylamine hydrochloride; sodium methylate; In methanol; for 8h; Reflux;

DOI:10.1007/s12039-020-01769-2

Reference yield:

4-chloro-phenol (106-48-9,82344-39-6) → 2-(4-chlorophenoxy)acetohydroxamic acid (13359-17-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / Reflux

2: sodium methylate; hydroxylamine hydrochloride / methanol / 20 °C

With hydroxylamine hydrochloride; sodium methylate; potassium carbonate; In methanol; acetone; 1: |Williamson Ether Synthesis;

DOI:10.1016/j.bmc.2018.07.003

upstream raw materials:

ethyl p-chlorophenoxyacetate

(4-chloro-phenoxy)-acetic acid methyl ester

4-chloro-phenol

Downstream raw materials:

2-(4-chloro-phenoxy)-N-hydroxy-N-morpholin-4-ylmethyl-acetamide

2-(4-Chloro-phenoxy)-N-dimethylaminomethyl-N-hydroxy-acetamide

2-(4-Chloro-phenoxy)-N-diethylaminomethyl-N-hydroxy-acetamide

6-chloro-2H-1,4-benzoxazin-3(4H)-one