3-amino-2,2-dimethylcyclobutanol

Base Information

• Chemical Name: 3-amino-2,2-dimethylcyclobutanol
• CAS No.: 1434247-99-0
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.175
• Mol file: 1434247-99-0.mol

Synonyms:

Chemical Property of 3-amino-2,2-dimethylcyclobutanol

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

3-amino-2,2-dimethylcyclobutan-1-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-amino-2,2-dimethylcyclobutanol

There total 7 articles about 3-amino-2,2-dimethylcyclobutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (3-hydroxy-2,2-dimethylcyclobutyl)carbamate (1434141-79-3,1434141-89-5) → 3-amino-2,2-dimethylcyclobutanol (1434247-99-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 0.5h;

Reference yield:

3-ethoxy-2,2-dimethylcyclobutan-1-amine → 3-amino-2,2-dimethylcyclobutanol (1434247-99-0)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 - 10 ℃; Large scale;

DOI:10.1021/acs.jmedchem.1c00388

Reference yield:

3-ethoxy-2,2-dimethylcyclobutan-1-one (2292-84-4) → 3-amino-2,2-dimethylcyclobutanol (1434247-99-0)

Guidance literature:

Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium hydrogencarbonate / methanol / 20 °C / Large scale

2: ammonium hydroxide; hydrogen / methanol / 5 h / 27 °C / 2585.81 Torr / Large scale

3: boron tribromide / dichloromethane / 0 - 10 °C / Large scale

With ammonium hydroxide; hydroxylamine hydrochloride; hydrogen; boron tribromide; sodium hydrogencarbonate; In methanol; dichloromethane;

DOI:10.1021/acs.jmedchem.1c00388

upstream raw materials:

2,2-dimethyl-3-oxo-cyclobutanecarboxylic acid methyl ester

2,2-dimethyl-3-oxocyclobutanecarboxylic acid

tert-butyl (2,2-dimethyl-3-oxocyclobutyl)carbamate

tert-butyl (3-hydroxy-2,2-dimethylcyclobutyl)carbamate

Refernces

• 1、 -. "SUBSTITUTED DIAMINOPYRIMIDYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH". . . Retrieved 2015/07/02.