4'-Iodo-biphenyl-3-carboxylic acid (3R,5S,8S,9R,10S,13S,14S)-9-fluoro-10,13-dimethyl-11,17-dioxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Base Information

Chemical Name:4'-Iodo-biphenyl-3-carboxylic acid (3R,5S,8S,9R,10S,13S,14S)-9-fluoro-10,13-dimethyl-11,17-dioxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester
CAS No.:143539-78-0
Molecular Formula:C₃₂H₃₄FIO₄
Molecular Weight:628.522
Hs Code.:

4'-Iodo-biphenyl-3-carboxylic acid (3R,5S,8S,9R,10S,13S,14S)-9-fluoro-10,13-dimethyl-11,17-dioxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Synonyms:

Suppliers and Price of 4'-Iodo-biphenyl-3-carboxylic acid (3R,5S,8S,9R,10S,13S,14S)-9-fluoro-10,13-dimethyl-11,17-dioxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4'-Iodo-biphenyl-3-carboxylic acid (3R,5S,8S,9R,10S,13S,14S)-9-fluoro-10,13-dimethyl-11,17-dioxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4'-Iodo-biphenyl-3-carboxylic acid (3R,5S,8S,9R,10S,13S,14S)-9-fluoro-10,13-dimethyl-11,17-dioxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

There total 12 articles about 4'-Iodo-biphenyl-3-carboxylic acid (3R,5S,8S,9R,10S,13S,14S)-9-fluoro-10,13-dimethyl-11,17-dioxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4'-Iodo-biphenyl-3-carboxylic acid (3R,5S,8S,9R,10S,13S,14S)-17-[1,5-dimethyl-hex-(E)-ylidene]-9-fluoro-10,13-dimethyl-11-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

: 143539-78-0
4'-Iodo-biphenyl-3-carboxylic acid (3R,5S,8S,9R,10S,13S,14S)-9-fluoro-10,13-dimethyl-11,17-dioxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Guidance literature:: With ozone; In dichloromethane; Yield given;
DOI:10.1016/S0040-4039(00)74674-0

Reference yield:

: 80-97-7
Cholestanol

: 143539-78-0
4'-Iodo-biphenyl-3-carboxylic acid (3R,5S,8S,9R,10S,13S,14S)-9-fluoro-10,13-dimethyl-11,17-dioxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 96 percent / Ph₃P, DIAD

2: 1.) PhICl₂, 2.) KOH / 1.) irradiation

5: HF

6: PCC

7: KOH / methanol / Ambient temperature

8: 10percent pyridine, DMAP / benzene / Heating

9: PhICl₂ / CH₂Cl₂; 2-methyl-propan-2-ol / Irradiation

10: DBU

11: O₃ / CH₂Cl₂

With pyridine; dmap; potassium hydroxide; di-isopropyl azodicarboxylate; (Dichloroiodo)benzene; hydrogen fluoride; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; pyridinium chlorochromate; In methanol; dichloromethane; tert-butyl alcohol; benzene;
DOI:10.1016/S0040-4039(00)74674-0

Reference yield:

: 37772-03-5
Cholest-Δ⁹⁽¹¹⁾-3-en-3α-yl acetate

: 143539-78-0
4'-Iodo-biphenyl-3-carboxylic acid (3R,5S,8S,9R,10S,13S,14S)-9-fluoro-10,13-dimethyl-11,17-dioxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Guidance literature:: Multi-step reaction with 8 steps

2: HF

3: PCC

4: KOH / methanol / Ambient temperature

5: 10percent pyridine, DMAP / benzene / Heating

6: PhICl₂ / CH₂Cl₂; 2-methyl-propan-2-ol / Irradiation

7: DBU

8: O₃ / CH₂Cl₂

With pyridine; dmap; potassium hydroxide; (Dichloroiodo)benzene; hydrogen fluoride; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; pyridinium chlorochromate; In methanol; dichloromethane; tert-butyl alcohol; benzene;
DOI:10.1016/S0040-4039(00)74674-0