r-1,c-2,c-4-cyclohexanetricarboxylic acid

Base Information

• Chemical Name: r-1,c-2,c-4-cyclohexanetricarboxylic acid
• CAS No.: 21793-92-0
• Molecular Formula: C₉H₁₂O₆
• Molecular Weight: 216.191
• Mol file: 21793-92-0.mol

Synonyms:

Chemical Property of r-1,c-2,c-4-cyclohexanetricarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of r-1,c-2,c-4-cyclohexanetricarboxylic acid

There total 23 articles about r-1,c-2,c-4-cyclohexanetricarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

1,2,4-benzene tricarboxylic acid (528-44-9) → r-1,c-2,c-4-cyclohexanetricarboxylic acid (21793-92-0,21793-93-1,21794-05-8,21794-06-9,23084-86-8,76784-95-7,145039-49-2)

Guidance literature:

With hydrogen; platinum(IV) oxide; In acetic acid; Ambient temperature;

DOI:10.1248/cpb.28.2337

Reference yield:

dimethyl 4-cyanophthalate (51927-06-1) → (1S,2R,4S)-Cyclohexane-1,2,4-tricarboxylic acid (21793-92-0,21793-93-1,21794-05-8,21794-06-9,23084-86-8,76784-95-7,145039-49-2)

Guidance literature:

Multi-step reaction with 6 steps

1: H₂, conc. NH₄OH / Raney Ni / methanol / 12 h / Ambient temperature

2: 1 N NaOH / 1 h / Heating

3: 61 percent / H₂, 0.5 HCl / PtO₂ / 20 h / 30 - 40 °C

4: 16 percent / 1 N NaOH / 16 h / 180 - 200 °C

5: 0.9 percent / 2 N NaOH / 60 h / 180 - 200 °C

6: KMnO₄

With hydrogenchloride; ammonium hydroxide; sodium hydroxide; potassium permanganate; hydrogen; platinum(IV) oxide; nickel; In methanol;

DOI:10.1248/cpb.28.2337

Reference yield:

dimethyl 4-cyanophthalate (51927-06-1) → r-1,c-2,c-4-cyclohexanetricarboxylic acid (21793-92-0,21793-93-1,21794-05-8,21794-06-9,23084-86-8,76784-95-7,145039-49-2)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂, conc. NH₄OH / Raney Ni / methanol / 12 h / Ambient temperature

2: 1 N NaOH / 1 h / Heating

3: 61 percent / H₂, 0.5 HCl / PtO₂ / 20 h / 30 - 40 °C

4: KMnO₄

With hydrogenchloride; ammonium hydroxide; sodium hydroxide; potassium permanganate; hydrogen; platinum(IV) oxide; nickel; In methanol;

DOI:10.1248/cpb.28.2337

upstream raw materials:

c-4-aminomethyl-r-1,t-2-cyclohexanedicarboxylic acid

dimethyl 4-cyanophthalate

4-aminomethylphthalic acid

4-Aminomethyl-phthalic acid dimethyl ester

Downstream raw materials:

trimethyl r-1,c-2,c-4-cyclohexanetricarboxylate

trimethyl r-1,c-2,t-4-cyclohexanetricarboxylate

trimethyl r-1,t-2,t-4-cyclohexanetricarboxylate

trimethyl r-1,t-2,c-4-cyclohexanetricarboxylate

Refernces