methyl 6-(allyloxy)-8-<(benzyloxy)methoxy>-1-hydroxy-3-<(2'R,3'S,4'R,5'S,6'R)-3'-methoxy-5',6'-(cyclohexylidenedioxy)-4'-<(tert-butyldimethylsilyl)oxy>-2'-vinylheptyl>naphthoate

Base Information

Chemical Name:methyl 6-(allyloxy)-8-<(benzyloxy)methoxy>-1-hydroxy-3-<(2'R,3'S,4'R,5'S,6'R)-3'-methoxy-5',6'-(cyclohexylidenedioxy)-4'-<(tert-butyldimethylsilyl)oxy>-2'-vinylheptyl>naphthoate
CAS No.:144108-08-7
Molecular Formula:C₄₅H₆₂O₁₀Si
Molecular Weight:791.067
Hs Code.:

methyl 6-(allyloxy)-8-<(benzyloxy)methoxy>-1-hydroxy-3-<(2'R,3'S,4'R,5'S,6'R)-3'-methoxy-5',6'-(cyclohexylidenedioxy)-4'-<(tert-butyldimethylsilyl)oxy>-2'-vinylheptyl>naphthoate

Synonyms:

Suppliers and Price of methyl 6-(allyloxy)-8-<(benzyloxy)methoxy>-1-hydroxy-3-<(2'R,3'S,4'R,5'S,6'R)-3'-methoxy-5',6'-(cyclohexylidenedioxy)-4'-<(tert-butyldimethylsilyl)oxy>-2'-vinylheptyl>naphthoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 6-(allyloxy)-8-<(benzyloxy)methoxy>-1-hydroxy-3-<(2'R,3'S,4'R,5'S,6'R)-3'-methoxy-5',6'-(cyclohexylidenedioxy)-4'-<(tert-butyldimethylsilyl)oxy>-2'-vinylheptyl>naphthoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 6-(allyloxy)-8-<(benzyloxy)methoxy>-1-hydroxy-3-<(2'R,3'S,4'R,5'S,6'R)-3'-methoxy-5',6'-(cyclohexylidenedioxy)-4'-<(tert-butyldimethylsilyl)oxy>-2'-vinylheptyl>naphthoate

There total 2 articles about methyl 6-(allyloxy)-8-<(benzyloxy)methoxy>-1-hydroxy-3-<(2'R,3'S,4'R,5'S,6'R)-3'-methoxy-5',6'-(cyclohexylidenedioxy)-4'-<(tert-butyldimethylsilyl)oxy>-2'-vinylheptyl>naphthoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 144108-04-3
methyl 4-(allyloxy)-6-<(5'S,6'R,7'S,8'R)-6'-<(tert-butyldimethylsilyl)oxy>-7',8'-(cyclohexylidenedioxy)-5'-methoxy-2'-oxonon-3'(E)-enyl>-2-hydroxybenzoate

: 144108-08-7
methyl 6-(allyloxy)-8-<(benzyloxy)methoxy>-1-hydroxy-3-<(2'R,3'S,4'R,5'S,6'R)-3'-methoxy-5',6'-(cyclohexylidenedioxy)-4'-<(tert-butyldimethylsilyl)oxy>-2'-vinylheptyl>naphthoate

Guidance literature:: Multi-step reaction with 2 steps

2: 2) AcOH / 1) THF, DMSO, hexane, 0 deg C, 10 min, 2) 23 deg C, 48 h

With acetic acid;
DOI:10.1021/jo00050a047

Reference yield:

: 6-(allyloxy)-8-<(benzyloxy)methoxy>-3-<(2'R,3'S,4'R,5'S,6'R)-4'-<(tert-butyldimethylsilyl)oxy>-5',6'-(cyclohexylidenedioxy)-5'-methoxy-2'-vinylheptyl>benzopyran-1-one

: methyl 2-lithioacetate

: 144108-08-7
methyl 6-(allyloxy)-8-<(benzyloxy)methoxy>-1-hydroxy-3-<(2'R,3'S,4'R,5'S,6'R)-3'-methoxy-5',6'-(cyclohexylidenedioxy)-4'-<(tert-butyldimethylsilyl)oxy>-2'-vinylheptyl>naphthoate

Guidance literature:: With acetic acid; Yield given. Multistep reaction; 1) THF, DMSO, hexane, 0 deg C, 10 min, 2) 23 deg C, 48 h;
DOI:10.1021/jo00050a047

Reference yield:

: 144108-08-7
methyl 6-(allyloxy)-8-<(benzyloxy)methoxy>-1-hydroxy-3-<(2'R,3'S,4'R,5'S,6'R)-3'-methoxy-5',6'-(cyclohexylidenedioxy)-4'-<(tert-butyldimethylsilyl)oxy>-2'-vinylheptyl>naphthoate

: methyl 8,9-bis<(benzyloxy)methoxy>-1-hydroxy-3-<(2'R,3'S,4'R,5'S,6'R)-3'-methoxy-5',6'-(cyclohexylidenedioxy)-4'-<(tert-butyldimethylsilyl)oxy>-2'-vinylheptyl>naphthoate

Guidance literature:: Multi-step reaction with 2 steps

1: NaH / dimethylformamide; tetrahydrofuran / 0.25 h / 23 °C

2: Bu₃SnH, AcOH / Pd(PPh₃)4 / toluene / 0.17 h / 23 °C

With tri-n-butyl-tin hydride; sodium hydride; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00050a047