(4'aR,7'aR)-6',7'a-bis(4-fluorophenyl)-4'a,7'a-dihydrospiro<1,2,4>trioxine>

Base Information

• Chemical Name: (4'aR,7'aR)-6',7'a-bis(4-fluorophenyl)-4'a,7'a-dihydrospiro<1,2,4>trioxine>
• CAS No.: 150780-56-6
• Molecular Formula: C₂₂H₂₀F₂O₃
• Molecular Weight: 370.396
• Mol file: 150780-56-6.mol

Synonyms:

Chemical Property of (4'aR,7'aR)-6',7'a-bis(4-fluorophenyl)-4'a,7'a-dihydrospiro<1,2,4>trioxine>

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4'aR,7'aR)-6',7'a-bis(4-fluorophenyl)-4'a,7'a-dihydrospiro<1,2,4>trioxine>

There total 5 articles about (4'aR,7'aR)-6',7'a-bis(4-fluorophenyl)-4'a,7'a-dihydrospiro<1,2,4>trioxine> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclopentanone (120-92-3) + 1,4-Bis-(4-fluoro-phenyl)-2,3-dioxa-bicyclo[2.2.1]hept-5-ene (852371-79-0) → (4'aS,7'aS)-6',7'a-bis(4-fluorophenyl)-4'a,7'a-dihydrospiro<1,2,4>trioxine> + (4'aR,7'aR)-6',7'a-bis(4-fluorophenyl)-4'a,7'a-dihydrospiro<1,2,4>trioxine> (150780-56-6)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -78 ℃; for 4h;

DOI:10.1002/hlca.19950780312

Reference yield:

C25H27F2NO5 → (4'aS,7'aS)-6',7'a-bis(4-fluorophenyl)-4'a,7'a-dihydrospiro<1,2,4>trioxine> + (4'aR,7'aR)-6',7'a-bis(4-fluorophenyl)-4'a,7'a-dihydrospiro<1,2,4>trioxine> (150780-56-6)

Guidance literature:

With trifluoromethylsulfonic anhydride; N-ethyl-N,N-diisopropylamine; In toluene; for 1h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;

DOI:10.1039/c39950001501

Reference yield:

(4'aRS,7'aRS)-6',7'a-bis(4-fluorophenyl)-4'a,7'a-dihydrospiro<1,2,4>trioxine> → (4'aS,7'aS)-6',7'a-bis(4-fluorophenyl)-4'a,7'a-dihydrospiro<1,2,4>trioxine> + (4'aR,7'aR)-6',7'a-bis(4-fluorophenyl)-4'a,7'a-dihydrospiro<1,2,4>trioxine> (150780-56-6) + C22H22F2O5 + C22H22F2O5

Guidance literature:

With potassium osmate(VI); 4-methylmorpholine N-oxide; (9S,9"S)-9,9"-[phthalazine-1,4-diylbis-(oxy)]bis[10,11-dihydro-6'-methoxycinchonane]; In water; acetone; at 25 ℃; for 0.583333h; Product distribution; var. of reagent, ratio, time;

DOI:10.1039/c39950001501

upstream raw materials:

cyclopentanone

1,4-Bis-(4-fluoro-phenyl)-2,3-dioxa-bicyclo[2.2.1]hept-5-ene