Technology Process of diphenylmethyl 7α-formamido-3-<(1-methyl-1H-tetrazol-5-yl)thiomethyl>-7β-<(4-nitrobenzyloxy)carbonylamino>ceph-3-em-4-carboxylate
There total 8 articles about diphenylmethyl 7α-formamido-3-<(1-methyl-1H-tetrazol-5-yl)thiomethyl>-7β-<(4-nitrobenzyloxy)carbonylamino>ceph-3-em-4-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 64 percent / pyridine / tetrahydrofuran / Ambient temperature
2: 78 percent / TFA / 0.75 h / Ambient temperature
3: 1,2-dichloro-ethane / 6.5 h / Heating
4: CH2Cl2 / 0.5 h / Ambient temperature
With
pyridine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 97 percent / pyridine / CH2Cl2 / 0 °C
2: 85 percent / mercury(II) acetate, ammonia / dimethylformamide / -40 degC then allowed to warm to room temperature
3: 75 percent / pyridine / CH2Cl2
4: 45 percent / potassium dihydrogen phosphate, zinc / 6 h
5: 64 percent / pyridine / tetrahydrofuran / Ambient temperature
6: 78 percent / TFA / 0.75 h / Ambient temperature
7: 1,2-dichloro-ethane / 6.5 h / Heating
8: CH2Cl2 / 0.5 h / Ambient temperature
With
pyridine; potassium dihydrogenphosphate; mercury(II) diacetate; ammonia; trifluoroacetic acid; zinc;
In
tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 85 percent / mercury(II) acetate, ammonia / dimethylformamide / -40 degC then allowed to warm to room temperature
2: 75 percent / pyridine / CH2Cl2
3: 45 percent / potassium dihydrogen phosphate, zinc / 6 h
4: 64 percent / pyridine / tetrahydrofuran / Ambient temperature
5: 78 percent / TFA / 0.75 h / Ambient temperature
6: 1,2-dichloro-ethane / 6.5 h / Heating
7: CH2Cl2 / 0.5 h / Ambient temperature
With
pyridine; potassium dihydrogenphosphate; mercury(II) diacetate; ammonia; trifluoroacetic acid; zinc;
In
tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
