benzofuro[3,2-c]quinoline

Base Information

• Chemical Name: benzofuro[3,2-c]quinoline
• CAS No.: 57305-59-6
• Molecular Formula: C₁₅H₉NO
• Molecular Weight: 219.243
• Mol file: 57305-59-6.mol

Synonyms:

Chemical Property of benzofuro[3,2-c]quinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzofuro[3,2-c]quinoline

There total 3 articles about benzofuro[3,2-c]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-bromo-4-(2-bromophenoxy)quinoline + phenylboronic acid (98-80-6) → benzofuro[3,2-c]quinoline (57305-59-6) + 2-phenylbenzofuro[3,2-c]quinoline

Guidance literature:

With C₃₄H₂₆Br₂N₂O₆Pd; potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 135 ℃; for 18h;

DOI:10.1021/acs.joc.9b03321

Reference yield:

6-bromo-4-chloroquinoline (65340-70-7) → benzofuro[3,2-c]quinoline (57305-59-6) + 2-phenylbenzofuro[3,2-c]quinoline

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / 120 °C

2: C₃₄H₂₆Br₂N₂O₆Pd; potassium carbonate / 1-methyl-pyrrolidin-2-one / 18 h / 135 °C

With C₃₄H₂₆Br₂N₂O₆Pd; potassium carbonate; sodium hydroxide; In 1-methyl-pyrrolidin-2-one;

DOI:10.1021/acs.joc.9b03321

Reference yield:

2-hydroxybromobenzene (95-56-7) → benzofuro[3,2-c]quinoline (57305-59-6) + 2-phenylbenzofuro[3,2-c]quinoline

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / 120 °C

2: C₃₄H₂₆Br₂N₂O₆Pd; potassium carbonate / 1-methyl-pyrrolidin-2-one / 18 h / 135 °C

With C₃₄H₂₆Br₂N₂O₆Pd; potassium carbonate; sodium hydroxide; In 1-methyl-pyrrolidin-2-one;

DOI:10.1021/acs.joc.9b03321

upstream raw materials:

phenylboronic acid

6-bromo-4-chloroquinoline

2-hydroxybromobenzene