(trans)-4-Propyl-1-methyl-L-proline

Base Information

• Chemical Name: (trans)-4-Propyl-1-methyl-L-proline
• CAS No.: 13380-36-4
• Molecular Formula: C9H17NO2
• Molecular Weight: 171.239
• Hs Code.: 2933990090
• Mol file: 13380-36-4.mol

Synonyms:(2S,4Z)-1-methyl-4-propylidenepyrrolidine-2-carboxylic acid;

Chemical Property of (trans)-4-Propyl-1-methyl-L-proline

Chemical Property:

• Boiling Point: 268.0±33.0 °C(Predicted)
• PKA: 2.37±0.40(Predicted)
• PSA: 40.54000
• Density: 1.030±0.06 g/cm3(Predicted)
• LogP: 1.12930

Purity/Quality:

97% ^*data from raw suppliers

(trans)-4-Propyl-1-methyl-L-proline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (trans)-4-Propyl-1-methyl-L-proline (cas# 13380-36-4) is a compound useful in organic synthesis.

Technology Process of (trans)-4-Propyl-1-methyl-L-proline

There total 2 articles about (trans)-4-Propyl-1-methyl-L-proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

lincomycin (154-21-2) → 1-methyl-4-propylpyrrolidine-2-carboxylic acid (13380-36-4) + α-methylthiolincosaminide (14810-93-6)

Guidance literature:

With sodium hydroxide; at 95 - 110 ℃; for 22h; Product distribution; other compounds, other products;

DOI:10.1021/ja00337a038

Reference yield:

→ 1-methyl-4-propylpyrrolidine-2-carboxylic acid (13380-36-4)

Guidance literature:

entspr. Amid;

Reference yield: 90.0%

C9H19ClNO7PS + 1-methyl-4-propylpyrrolidine-2-carboxylic acid (13380-36-4) → clindamycin phosphate (24729-96-2)

Guidance literature:

With sodium carbonate; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; at 30 ℃; for 8h; Reagent/catalyst; Temperature;

upstream raw materials:

lincomycin

Downstream raw materials:

clindamycin phosphate

Refernces