C₂₂H₂₅FN₆O

Base Information

Chemical Name:C₂₂H₂₅FN₆O
CAS No.:1272598-76-1
Molecular Formula:C₂₂H₂₅FN₆O
Molecular Weight:408.479
Hs Code.:

C<sub>22</sub>H<sub>25</sub>FN<sub>6</sub>O

Synonyms:

Suppliers and Price of C₂₂H₂₅FN₆O

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₂H₂₅FN₆O

Chemical Property:

Purity/Quality:

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Technology Process of C₂₂H₂₅FN₆O

There total 12 articles about C₂₂H₂₅FN₆O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1272599-25-3
C₁₈H₂₇NO₅

: 1272598-76-1
C₂₂H₂₅FN₆O

Guidance literature:: Multi-step reaction with 8 steps

1.1: formic acid; di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / Reflux

1.2: 20 °C

2.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / -78 - 20 °C

3.1: 10% palladium on activated charcoal; hydrogen / methanol

4.1: triethylamine / dichloromethane

5.1: sodium azide / N,N-dimethyl-formamide / 50 - 60 °C

6.1: 5% Pd(II)/C(eggshell); hydrogen / ethanol

7.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / N,N-dimethyl-formamide

8.1: trifluoroacetic acid / dichloromethane

With formic acid; sodium azide; di-isopropyl azodicarboxylate; 5% Pd(II)/C(eggshell); 10% palladium on activated charcoal; hydrogen; triethylamine; triphenylphosphine; trifluoroacetic acid; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 1.1: Mitsunobu reaction / 1.2: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2010.12.078

Reference yield:

: 1272598-50-1
C₁₈H₂₇NO₅

: 1272598-76-1
C₂₂H₂₅FN₆O

Guidance literature:: Multi-step reaction with 7 steps

1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / -78 - 20 °C

2: 10% palladium on activated charcoal; hydrogen / methanol

3: triethylamine / dichloromethane

4: sodium azide / N,N-dimethyl-formamide / 50 - 60 °C

5: 5% Pd(II)/C(eggshell); hydrogen / ethanol

6: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / N,N-dimethyl-formamide

7: trifluoroacetic acid / dichloromethane

With sodium azide; 5% Pd(II)/C(eggshell); 10% palladium on activated charcoal; hydrogen; triethylamine; trifluoroacetic acid; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2010.12.078

Reference yield:

: 1272598-52-3
C₁₈H₂₆FNO₄

: 1272598-76-1
C₂₂H₂₅FN₆O

Guidance literature:: Multi-step reaction with 6 steps

1: 10% palladium on activated charcoal; hydrogen / methanol

2: triethylamine / dichloromethane

3: sodium azide / N,N-dimethyl-formamide / 50 - 60 °C

4: 5% Pd(II)/C(eggshell); hydrogen / ethanol

5: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / N,N-dimethyl-formamide

6: trifluoroacetic acid / dichloromethane

With sodium azide; 5% Pd(II)/C(eggshell); 10% palladium on activated charcoal; hydrogen; triethylamine; trifluoroacetic acid; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2010.12.078