<4S^*-(4α,4aα,8aα)>-4a,5,6,7,8,8a-hexahydro-4-methyl-8a-(4-morpholinyl)-8-oxo-3-phenyl-4H-1,2-benzoxazine N-oxide

Base Information

• Chemical Name: <4S^*-(4α,4aα,8aα)>-4a,5,6,7,8,8a-hexahydro-4-methyl-8a-(4-morpholinyl)-8-oxo-3-phenyl-4H-1,2-benzoxazine N-oxide
• CAS No.: 114390-78-2
• Molecular Formula: C₁₉H₂₄N₂O₄
• Molecular Weight: 344.411

Synonyms:

Chemical Property of <4S^*-(4α,4aα,8aα)>-4a,5,6,7,8,8a-hexahydro-4-methyl-8a-(4-morpholinyl)-8-oxo-3-phenyl-4H-1,2-benzoxazine N-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of <4S^*-(4α,4aα,8aα)>-4a,5,6,7,8,8a-hexahydro-4-methyl-8a-(4-morpholinyl)-8-oxo-3-phenyl-4H-1,2-benzoxazine N-oxide

There total 3 articles about <4S^*-(4α,4aα,8aα)>-4a,5,6,7,8,8a-hexahydro-4-methyl-8a-(4-morpholinyl)-8-oxo-3-phenyl-4H-1,2-benzoxazine N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-nitro-1-phenylmethane (622-42-4) → <4S*-(4α,4aα,8aα)>-4a,5,6,7,8,8a-hexahydro-4-methyl-8a-(4-morpholinyl)-8-oxo-3-phenyl-4H-1,2-benzoxazine N-oxide (114390-78-2)

Guidance literature:

Multi-step reaction with 3 steps

1: basic aluminium oxide / 1.) 0 deg C, 5 h, 2.) room temperature, 20 h

2: methanesulfonyl chloride, triethylamine / CH₂Cl₂ / 0.75 h / 0 °C

3: neat (no solvent) / 12 h / Ambient temperature

With aluminum oxide; methanesulfonyl chloride; triethylamine; In dichloromethane;

DOI:10.1016/S0040-4020(01)90296-0

Reference yield:

1-nitro-1-phenyl-2-propanol (62634-59-7) → <4S*-(4α,4aα,8aα)>-4a,5,6,7,8,8a-hexahydro-4-methyl-8a-(4-morpholinyl)-8-oxo-3-phenyl-4H-1,2-benzoxazine N-oxide (114390-78-2)

Guidance literature:

Multi-step reaction with 2 steps

1: methanesulfonyl chloride, triethylamine / CH₂Cl₂ / 0.75 h / 0 °C

2: neat (no solvent) / 12 h / Ambient temperature

With methanesulfonyl chloride; triethylamine; In dichloromethane;

DOI:10.1016/S0040-4020(01)90296-0

Reference yield:

2-phenyl-1-nitroprop-1-ene (25236-39-9) + 2-morpholinocyclohex-2-enone (23740-64-9) → <4S*-(4α,4aα,8aα)>-4a,5,6,7,8,8a-hexahydro-4-methyl-8a-(4-morpholinyl)-8-oxo-3-phenyl-4H-1,2-benzoxazine N-oxide (114390-78-2)

Guidance literature:

In neat (no solvent); for 12h; Ambient temperature;

DOI:10.1016/S0040-4020(01)90296-0

upstream raw materials:

2-phenyl-1-nitroprop-1-ene

2-morpholinocyclohex-2-enone

1-nitro-1-phenylmethane

1-nitro-1-phenyl-2-propanol

Downstream raw materials:

<2R^*-(2α,3α,3aα,6aα)>hexahydro-3-methyl-6a-(4-morpholinyl)-2-nitro-2-phenyl-1(2H)-pentalenone

<2S^*-(2α,3β,3aβ,6aβ)>hexahydro-3-methyl-6a-(4-morpholinyl)-2-nitro-2-phenyl-1(2H)-pentalenone

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