(R)-2-Acetyl-3-(3,4-dimethoxy-phenyl)-4-{1-[(E)-(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-ylimino]-ethyl}-pentanedioic acid 5-tert-butyl ester 1-methyl ester

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Chemical Name:(R)-2-Acetyl-3-(3,4-dimethoxy-phenyl)-4-{1-[(E)-(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-ylimino]-ethyl}-pentanedioic acid 5-tert-butyl ester 1-methyl ester
CAS No.:121236-78-0
Molecular Formula:C₃₀H₄₆N₂O₈
Molecular Weight:562.704
Hs Code.:

(R)-2-Acetyl-3-(3,4-dimethoxy-phenyl)-4-{1-[(E)-(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-ylimino]-ethyl}-pentanedioic acid 5-tert-butyl ester 1-methyl ester

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Chemical Property of (R)-2-Acetyl-3-(3,4-dimethoxy-phenyl)-4-{1-[(E)-(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-ylimino]-ethyl}-pentanedioic acid 5-tert-butyl ester 1-methyl ester

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Technology Process of (R)-2-Acetyl-3-(3,4-dimethoxy-phenyl)-4-{1-[(E)-(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-ylimino]-ethyl}-pentanedioic acid 5-tert-butyl ester 1-methyl ester

There total 4 articles about (R)-2-Acetyl-3-(3,4-dimethoxy-phenyl)-4-{1-[(E)-(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-ylimino]-ethyl}-pentanedioic acid 5-tert-butyl ester 1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 121236-78-0
(R)-2-Acetyl-3-(3,4-dimethoxy-phenyl)-4-{1-[(E)-(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-ylimino]-ethyl}-pentanedioic acid 5-tert-butyl ester 1-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine / dioxane / 20 °C / further method: piperidine, HOAc, benzene, reflux

2: 1.) n-BuLi / 1.) -78 deg C, 10 min, 2.) -78 deg C, 1 h

With piperidine; n-butyllithium; In 1,4-dioxane;
DOI:10.1016/S0040-4039(00)82366-7

Reference yield:

: 1694-31-1
tert-butyl acetoacetate

: 121236-78-0
(R)-2-Acetyl-3-(3,4-dimethoxy-phenyl)-4-{1-[(E)-(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-ylimino]-ethyl}-pentanedioic acid 5-tert-butyl ester 1-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

2: 1.) n-BuLi / 1.) -78 deg C, 10 min, 2.) -78 deg C, 1 h

With n-butyllithium;
DOI:10.1016/S0040-4039(00)82366-7

Reference yield:

: 121224-35-9,118535-61-8
(S)-(-)-1-amino-2-(1'-methoxy-1'-methylethyl)pyrrolidine

: 121236-78-0
(R)-2-Acetyl-3-(3,4-dimethoxy-phenyl)-4-{1-[(E)-(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-ylimino]-ethyl}-pentanedioic acid 5-tert-butyl ester 1-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

2: 1.) n-BuLi / 1.) -78 deg C, 10 min, 2.) -78 deg C, 1 h

With n-butyllithium;
DOI:10.1016/S0040-4039(00)82366-7