ethyl 2-amino-2',5-dioxo-1',5'-diphenyl-3-cyano-1',2'-dihydro-5H-spiro{pyrano[3,2-c]-chromen-4,3'-pyrrole}-4'-carboxylate

Base Information

• Chemical Name: ethyl 2-amino-2',5-dioxo-1',5'-diphenyl-3-cyano-1',2'-dihydro-5H-spiro{pyrano[3,2-c]-chromen-4,3'-pyrrole}-4'-carboxylate
• CAS No.: 1334770-98-7
• Molecular Formula: C₃₁H₂₁N₃O₆
• Molecular Weight: 531.524
• Mol file: 1334770-98-7.mol

Synonyms:

Chemical Property of ethyl 2-amino-2',5-dioxo-1',5'-diphenyl-3-cyano-1',2'-dihydro-5H-spiro{pyrano[3,2-c]-chromen-4,3'-pyrrole}-4'-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-amino-2',5-dioxo-1',5'-diphenyl-3-cyano-1',2'-dihydro-5H-spiro{pyrano[3,2-c]-chromen-4,3'-pyrrole}-4'-carboxylate

There total 3 articles about ethyl 2-amino-2',5-dioxo-1',5'-diphenyl-3-cyano-1',2'-dihydro-5H-spiro{pyrano[3,2-c]-chromen-4,3'-pyrrole}-4'-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

4-hydroxy[1]benzopyran-2-one (1076-38-6,92395-12-5) + ethyl 4,5-dioxo-1,2-diphenyl-4,5-dihydro-1H-pyrrole-3-carboxylate (61429-66-1) + malononitrile (109-77-3) → ethyl 2-amino-2',5-dioxo-1',5'-diphenyl-3-cyano-1',2'-dihydro-5H-spiro{pyrano[3,2-c]-chromen-4,3'-pyrrole}-4'-carboxylate (1334770-98-7)

Guidance literature:

ethyl 4,5-dioxo-1,2-diphenyl-4,5-dihydro-1H-pyrrole-3-carboxylate; malononitrile; With triethylamine; In toluene; for 0.166667h; Reflux;

4-hydroxy[1]benzopyran-2-one; In toluene; for 0.416667h; Reflux;

DOI:10.1134/S1070428011080288

Reference yield:

ethyl 4,5-dioxo-1,2-diphenyl-4,5-dihydro-1H-pyrrole-3-carboxylate (61429-66-1) → ethyl 2-amino-2',5-dioxo-1',5'-diphenyl-3-cyano-1',2'-dihydro-5H-spiro{pyrano[3,2-c]-chromen-4,3'-pyrrole}-4'-carboxylate (1334770-98-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / toluene / 5 h / Reflux

2: toluene / 0.5 h / Reflux

With triethylamine; In toluene;

DOI:10.1134/S1070428015010121

Reference yield:

4-hydroxy[1]benzopyran-2-one (1076-38-6,92395-12-5) + C22H15N3O3 → ethyl 2-amino-2',5-dioxo-1',5'-diphenyl-3-cyano-1',2'-dihydro-5H-spiro{pyrano[3,2-c]-chromen-4,3'-pyrrole}-4'-carboxylate (1334770-98-7)

Guidance literature:

In toluene; for 0.5h; Reflux;

DOI:10.1134/S1070428015010121

upstream raw materials:

4-hydroxy[1]benzopyran-2-one

ethyl 4,5-dioxo-1,2-diphenyl-4,5-dihydro-1H-pyrrole-3-carboxylate

malononitrile