C₄₄H₄₂N₄O₇S

Base Information

• Chemical Name: C₄₄H₄₂N₄O₇S
• CAS No.: 1383737-48-1
• Molecular Formula: C₄₄H₄₂N₄O₇S
• Molecular Weight: 770.906
• Mol file: 1383737-48-1.mol

Synonyms:

Chemical Property of C₄₄H₄₂N₄O₇S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₄H₄₂N₄O₇S

There total 8 articles about C₄₄H₄₂N₄O₇S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-naphthalenesulphonamide (1576-47-2) + C34H35N3O6 (1383737-89-0) → C44H42N4O7S (1383737-48-1)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2012.04.106

Reference yield:

3-{[(1,1-dimethylethyl)oxy]carbonyl}benzoic acid (33704-19-7) → C44H42N4O7S (1383737-48-1)

Guidance literature:

Multi-step reaction with 8 steps

1.1: [bis(acetoxy)iodo]benzene; iodine; palladium diacetate; tetra-(n-butyl)ammonium iodide / 1,2-dichloro-ethane / 6 h / 80 °C

2.1: 2,6-dimethylpyridine; HATU / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 20 °C

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tri-n-octylsilane; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 70 °C

4.1: potassium tert-butylate / tetrahydrofuran / 3 h / 20 °C

5.1: dmap; acetic anhydride / tetrahydrofuran / 0.5 h / 20 °C

5.2: 16 h / 20 °C

6.1: potassium tert-butylate / tetrahydrofuran / -78 °C

6.2: 2 h / -78 °C

7.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

8.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

With 2,6-dimethylpyridine; dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; [bis(acetoxy)iodo]benzene; tri-n-octylsilane; potassium tert-butylate; iodine; palladium diacetate; acetic anhydride; tetra-(n-butyl)ammonium iodide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.04.106

Reference yield:

C12H13IO4 (1383737-72-1) → C44H42N4O7S (1383737-48-1)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 2,6-dimethylpyridine; HATU / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 20 °C

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tri-n-octylsilane; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 70 °C

3.1: potassium tert-butylate / tetrahydrofuran / 3 h / 20 °C

4.1: dmap; acetic anhydride / tetrahydrofuran / 0.5 h / 20 °C

4.2: 16 h / 20 °C

5.1: potassium tert-butylate / tetrahydrofuran / -78 °C

5.2: 2 h / -78 °C

6.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

7.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

With 2,6-dimethylpyridine; dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tri-n-octylsilane; potassium tert-butylate; acetic anhydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.04.106

upstream raw materials:

C₁₂H₁₃IO₄

C₂₁H₂₂INO₃

C₂₂H₂₃NO₄

C₂₇H₃₄N₂O₆