Leu-Ser(PO₃Ph₂)-Ser(PO₃Ph₂)-Ser(PO₃Ph₂)-Glu(OBzl)-Glu(OBzl)-NHMe trifluoroacetate

Base Information

• Chemical Name: Leu-Ser(PO₃Ph₂)-Ser(PO₃Ph₂)-Ser(PO₃Ph₂)-Glu(OBzl)-Glu(OBzl)-NHMe trifluoroacetate
• CAS No.: 118466-65-2
• Molecular Formula: C₂HF₃O₂*C₇₆H₈₄N₇O₂₂P₃
• Molecular Weight: 1654.48
• Mol file: 118466-65-2.mol

Synonyms:

Chemical Property of Leu-Ser(PO₃Ph₂)-Ser(PO₃Ph₂)-Ser(PO₃Ph₂)-Glu(OBzl)-Glu(OBzl)-NHMe trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Leu-Ser(PO₃Ph₂)-Ser(PO₃Ph₂)-Ser(PO₃Ph₂)-Glu(OBzl)-Glu(OBzl)-NHMe trifluoroacetate

There total 1 articles about Leu-Ser(PO₃Ph₂)-Ser(PO₃Ph₂)-Ser(PO₃Ph₂)-Glu(OBzl)-Glu(OBzl)-NHMe trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Boc-Leu-Ser(PO3Ph2)-Ser(PO3Ph2)-Ser(PO3Ph2)-Glu(OBzl)-Glu(OBzl)-NHMe (118466-63-0) → Leu-Ser(PO3Ph2)-Ser(PO3Ph2)-Ser(PO3Ph2)-Glu(OBzl)-Glu(OBzl)-NHMe trifluoroacetate (118466-65-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1071/CH9920385

Reference yield:

Nα-(t-butoxycarbonyl)-O-(diphenylphosphono)-L-serine (105751-07-3) + Leu-Ser(PO3Ph2)-Ser(PO3Ph2)-Ser(PO3Ph2)-Glu(OBzl)-Glu(OBzl)-NHMe trifluoroacetate (118466-65-2) → Boc-Ser(PO3Ph2)-Leu-Ser(PO3Ph2)-Ser(PO3Ph2)-Ser(PO3Ph2)-Glu(OBzl)-Glu(OBzl)-NHMe (118466-66-3)

Guidance literature:

With 4-methyl-morpholine; isobutyl chloroformate; Yield given. Multistep reaction; 1.) THF, -20 deg C, 3 min, 2.) THF, CH₂Cl₂, -20 deg C, 2 h;

DOI:10.1071/CH9920385

upstream raw materials:

Boc-Leu-Ser(PO₃Ph₂)-Ser(PO₃Ph₂)-Ser(PO₃Ph₂)-Glu(OBzl)-Glu(OBzl)-NHMe

Downstream raw materials:

Boc-Ser(PO₃Ph₂)-Leu-Ser(PO₃Ph₂)-Ser(PO₃Ph₂)-Ser(PO₃Ph₂)-Glu(OBzl)-Glu(OBzl)-NHMe