(3R)-(4-phenoxybutyl)-3-methylindolizidine

Base Information

• Chemical Name: (3R)-(4-phenoxybutyl)-3-methylindolizidine
• CAS No.: 118173-34-5
• Molecular Formula: C₁₉H₂₉NO
• Molecular Weight: 287.445
• Mol file: 118173-34-5.mol

Synonyms:

Chemical Property of (3R)-(4-phenoxybutyl)-3-methylindolizidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R)-(4-phenoxybutyl)-3-methylindolizidine

There total 5 articles about (3R)-(4-phenoxybutyl)-3-methylindolizidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

(4-phenoxybutyl)magnesium bromide + (R)-3-Methyl-hexahydro-indolizine-8a-carbonitrile (118173-35-6) → (3R)-(4-phenoxybutyl)-3-methylindolizidine (118173-34-5,118243-82-6)

Guidance literature:

In tetrahydrofuran; Heating;

Reference yield:

(S)-(-)-5-(Bromomethyl)-2-pyrrolidinone (72479-05-1) → (3R)-(4-phenoxybutyl)-3-methylindolizidine (118173-34-5,118243-82-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 85 percent / H₂, Et₃N, / 10percent Pd/C, / ethanol / 36 h / 760 Torr

2: 1.) KH, / 1.) DME, RT; 3 h, 2.) DME, RT; 8 h,

3: 1.) soda lime, 2.) HClO₄, / 1.) reflux, 2.) EtOH,

4: 78 percent

5: 45 percent / tetrahydrofuran / Heating

With perchloric acid; soda lime; hydrogen; potassium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol;

Reference yield:

(R)-(+)-5-methyl-2-pyrrolidinon (21395-93-7) → (3R)-(4-phenoxybutyl)-3-methylindolizidine (118173-34-5,118243-82-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) KH, / 1.) DME, RT; 3 h, 2.) DME, RT; 8 h,

2: 1.) soda lime, 2.) HClO₄, / 1.) reflux, 2.) EtOH,

3: 78 percent

4: 45 percent / tetrahydrofuran / Heating

With perchloric acid; soda lime; potassium hydride; In tetrahydrofuran;

upstream raw materials:

(R)-3-Methyl-hexahydro-indolizine-8a-carbonitrile

(R)-(+)-5-methyl-2-pyrrolidinon

(S)-(-)-5-(Bromomethyl)-2-pyrrolidinone

R-N-(4-carbethoxybutyl)-5-methyl-2-pyrrolidinone