N-benzyl-1-(3,4-dihydro-2H-benzo[h]chromen-2-yl)methanamine

Base Information

Chemical Name:N-benzyl-1-(3,4-dihydro-2H-benzo[h]chromen-2-yl)methanamine
CAS No.:1609235-63-3
Molecular Formula:C₂₁H₂₁NO
Molecular Weight:303.404
Hs Code.:

Synonyms:

Suppliers and Price of N-benzyl-1-(3,4-dihydro-2H-benzo[h]chromen-2-yl)methanamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-benzyl-1-(3,4-dihydro-2H-benzo[h]chromen-2-yl)methanamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-benzyl-1-(3,4-dihydro-2H-benzo[h]chromen-2-yl)methanamine

There total 8 articles about N-benzyl-1-(3,4-dihydro-2H-benzo[h]chromen-2-yl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 92965-13-4
ethyl 4-oxo-4H-benzo[h]chromene-2-carboxylate

: 1609235-63-3
N-benzyl-1-(3,4-dihydro-2H-benzo[h]chromen-2-yl)methanamine

Guidance literature:: Multi-step reaction with 8 steps

1.1: palladium 10% on activated carbon; hydrogen / ethanol / 12 h

2.1: potassium hydroxide / water; isopropyl alcohol / 3 h / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / Reflux

4.1: triethylamine; dmap / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

4.2: 3 h / 20 °C / Inert atmosphere

5.1: sodium azide / N,N-dimethyl-formamide / 3 h / 60 °C / Inert atmosphere

6.1: triphenylphosphine / water; tetrahydrofuran / 20 °C / Inert atmosphere

7.1: triethylamine / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

8.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C

With dmap; lithium aluminium tetrahydride; sodium azide; palladium 10% on activated carbon; hydrogen; triethylamine; triphenylphosphine; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; 6.1: |Staudinger Azide Reduction;
DOI:10.1016/j.bmcl.2014.04.053

Reference yield:

: 1609235-52-0
(3,4-dihydro-2H-benzo[h]chromen-2-yl)methanol

: 1609235-63-3
N-benzyl-1-(3,4-dihydro-2H-benzo[h]chromen-2-yl)methanamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; dmap / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

1.2: 3 h / 20 °C / Inert atmosphere

2.1: sodium azide / N,N-dimethyl-formamide / 3 h / 60 °C / Inert atmosphere

3.1: triphenylphosphine / water; tetrahydrofuran / 20 °C / Inert atmosphere

4.1: triethylamine / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C

With dmap; lithium aluminium tetrahydride; sodium azide; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 3.1: |Staudinger Azide Reduction;
DOI:10.1016/j.bmcl.2014.04.053

Reference yield:

: 169747-40-4
ethyl 3,4-dihydro-2H-benzo[h]chromene-2-carboxylate

: 1609235-63-3
N-benzyl-1-(3,4-dihydro-2H-benzo[h]chromen-2-yl)methanamine

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hydroxide / water; isopropyl alcohol / 3 h / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / Reflux

3.1: triethylamine; dmap / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3.2: 3 h / 20 °C / Inert atmosphere

4.1: sodium azide / N,N-dimethyl-formamide / 3 h / 60 °C / Inert atmosphere

5.1: triphenylphosphine / water; tetrahydrofuran / 20 °C / Inert atmosphere

6.1: triethylamine / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C

With dmap; lithium aluminium tetrahydride; sodium azide; triethylamine; triphenylphosphine; potassium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; 5.1: |Staudinger Azide Reduction;
DOI:10.1016/j.bmcl.2014.04.053