3-((2E,4Z)-5-chloro-5-(4-fluorophenyl)-2-(methoxycarbonyl)penta-2,4-dienyl)-1-methyl-1H-imidazol-3-iumhydrogensulfate

Base Information

• Chemical Name: 3-((2E,4Z)-5-chloro-5-(4-fluorophenyl)-2-(methoxycarbonyl)penta-2,4-dienyl)-1-methyl-1H-imidazol-3-iumhydrogensulfate
• CAS No.: 1361123-95-6
• Molecular Formula: C₁₇H₁₇ClFN₂O₂*HO₄S
• Molecular Weight: 432.857
• Mol file: 1361123-95-6.mol

Synonyms:

Chemical Property of 3-((2E,4Z)-5-chloro-5-(4-fluorophenyl)-2-(methoxycarbonyl)penta-2,4-dienyl)-1-methyl-1H-imidazol-3-iumhydrogensulfate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-((2E,4Z)-5-chloro-5-(4-fluorophenyl)-2-(methoxycarbonyl)penta-2,4-dienyl)-1-methyl-1H-imidazol-3-iumhydrogensulfate

There total 3 articles about 3-((2E,4Z)-5-chloro-5-(4-fluorophenyl)-2-(methoxycarbonyl)penta-2,4-dienyl)-1-methyl-1H-imidazol-3-iumhydrogensulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-hexyl-3-methylimidazolium hydrogen sulphate (478935-29-4) + (Z)-methyl 5-chloro-5-(4-fluorophenyl)-3-hydroxy-2-methylenepent-4-enoate (1219452-55-7) → 3-((2E,4Z)-5-chloro-5-(4-fluorophenyl)-2-(methoxycarbonyl)penta-2,4-dienyl)-1-methyl-1H-imidazol-3-iumhydrogensulfate (1361123-95-6)

Guidance literature:

With sodium nitrate; at 80 ℃; for 11h; Ionic liquid;

DOI:10.3987/COM-11-12333

Reference yield:

1-(4-fluorophenyl)ethanone (403-42-9) → 3-((2E,4Z)-5-chloro-5-(4-fluorophenyl)-2-(methoxycarbonyl)penta-2,4-dienyl)-1-methyl-1H-imidazol-3-iumhydrogensulfate (1361123-95-6)

Guidance literature:

Multi-step reaction with 3 steps

1: bis(trichloromethyl) carbonate

2: 1,4-diaza-bicyclo[2.2.2]octane

3: sodium nitrate / 11 h / 80 °C / Ionic liquid

With 1,4-diaza-bicyclo[2.2.2]octane; sodium nitrate; bis(trichloromethyl) carbonate; 1: Vilsmeier formylation / 2: Baylis-Hillman reaction;

DOI:10.3987/COM-11-12333

Reference yield:

(Z)-3-chloro-3-(4-fluorophenyl)acrylaldehyde (161891-29-8) → 3-((2E,4Z)-5-chloro-5-(4-fluorophenyl)-2-(methoxycarbonyl)penta-2,4-dienyl)-1-methyl-1H-imidazol-3-iumhydrogensulfate (1361123-95-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,4-diaza-bicyclo[2.2.2]octane

2: sodium nitrate / 11 h / 80 °C / Ionic liquid

With 1,4-diaza-bicyclo[2.2.2]octane; sodium nitrate; 1: Baylis-Hillman reaction;

DOI:10.3987/COM-11-12333

upstream raw materials:

1-hexyl-3-methylimidazolium hydrogen sulphate

(Z)-methyl 5-chloro-5-(4-fluorophenyl)-3-hydroxy-2-methylenepent-4-enoate

1-(4-fluorophenyl)ethanone

(Z)-3-chloro-3-(4-fluorophenyl)acrylaldehyde