7-hydroxy-4-[3’-(1''H-imidazol-1''-yl)phenyl]-8-trifluoromethyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one

Base Information

Chemical Name:7-hydroxy-4-[3’-(1''H-imidazol-1''-yl)phenyl]-8-trifluoromethyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one
CAS No.:1453393-80-0
Molecular Formula:C₁₉H₁₃F₃N₄O₂
Molecular Weight:386.333
Hs Code.:

Synonyms:

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Chemical Property of 7-hydroxy-4-[3’-(1''H-imidazol-1''-yl)phenyl]-8-trifluoromethyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one

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Technology Process of 7-hydroxy-4-[3’-(1''H-imidazol-1''-yl)phenyl]-8-trifluoromethyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one

There total 10 articles about 7-hydroxy-4-[3’-(1''H-imidazol-1''-yl)phenyl]-8-trifluoromethyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35375-74-7
5-chloro-2-nitro-4-(trifluoromethyl)aniline

: 1453393-80-0
7-hydroxy-4-[3’-(1''H-imidazol-1''-yl)phenyl]-8-trifluoromethyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: potassium hydroxide; tetrabutylammomium bromide / 48 h / 60 °C

2: triethylamine; dmap / dichloromethane / 18 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

4: tin(II) chloride dihdyrate / ethanol / 6 h / 70 °C

5: toluene / 4 h / Reflux

6: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

7: boron tribromide / dichloromethane / 8 h

With dmap; tin(II) chloride dihdyrate; tetrabutylammomium bromide; boron tribromide; triethylamine; trifluoroacetic acid; potassium hydroxide; In ethanol; dichloromethane; toluene;
DOI:10.1039/c3md00110e

Reference yield:

: 400-70-4
2,4-dichloro-5-nitrobenzotrifluoride

: 1453393-80-0
7-hydroxy-4-[3’-(1''H-imidazol-1''-yl)phenyl]-8-trifluoromethyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1: ammonia / 1,4-dioxane / 144 h / 100 °C / Sealed tube

2: potassium hydroxide; tetrabutylammomium bromide / 48 h / 60 °C

3: triethylamine; dmap / dichloromethane / 18 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

5: tin(II) chloride dihdyrate / ethanol / 6 h / 70 °C

6: toluene / 4 h / Reflux

7: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

8: boron tribromide / dichloromethane / 8 h

With dmap; tin(II) chloride dihdyrate; tetrabutylammomium bromide; ammonia; boron tribromide; triethylamine; trifluoroacetic acid; potassium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; toluene;
DOI:10.1039/c3md00110e

Reference yield:

: 4518-10-9
Methyl 3-aminobenzoate

: 1453393-80-0
7-hydroxy-4-[3’-(1''H-imidazol-1''-yl)phenyl]-8-trifluoromethyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; methanol / 18 h / 20 °C

1.2: 1 h / Reflux

1.3: 5 h / Reflux

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 °C / Inert atmosphere

3.1: toluene / 4 h / Reflux

4.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

5.1: boron tribromide / dichloromethane / 8 h

With boron tribromide; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water; toluene; 2.1: |Claisen Condensation;
DOI:10.1039/c3md00110e