(7-(N-(2-hydroxyethyl)sulfamoyl)-3-(5-(2-morpholinoethoxy)-1H-indole-2-carbonyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate trifluoroacetate

Base Information

Chemical Name:(7-(N-(2-hydroxyethyl)sulfamoyl)-3-(5-(2-morpholinoethoxy)-1H-indole-2-carbonyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate trifluoroacetate
CAS No.:1363479-19-9
Molecular Formula:C₂HF₃O₂*C₃₇H₃₉N₅O₁₁S₂
Molecular Weight:907.9
Hs Code.:

(7-(N-(2-hydroxyethyl)sulfamoyl)-3-(5-(2-morpholinoethoxy)-1H-indole-2-carbonyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate trifluoroacetate

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Chemical Property of (7-(N-(2-hydroxyethyl)sulfamoyl)-3-(5-(2-morpholinoethoxy)-1H-indole-2-carbonyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate trifluoroacetate

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Technology Process of (7-(N-(2-hydroxyethyl)sulfamoyl)-3-(5-(2-morpholinoethoxy)-1H-indole-2-carbonyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate trifluoroacetate

There total 15 articles about (7-(N-(2-hydroxyethyl)sulfamoyl)-3-(5-(2-morpholinoethoxy)-1H-indole-2-carbonyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 885226-91-5
1-(1-(chloromethyl)-1H-benzo[e]indol-3(2H)-yl)-2,2,2-trifluoroethanone

: 1363479-19-9
(7-(N-(2-hydroxyethyl)sulfamoyl)-3-(5-(2-morpholinoethoxy)-1H-indole-2-carbonyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate trifluoroacetate

Guidance literature:: Multi-step reaction with 10 steps

1: sodium iodide / butanone / 17 h / 85 °C

2: 18-crown-6 ether / acetic acid / 120 h / 100 °C

3: chlorosulfonic acid / dichloromethane / -80 - 5 °C

4: oxalyl dichloride / N,N-dimethyl-formamide / 3 h / -10 - 5 °C

5: sulfuric acid; potassium nitrate / 0.25 h / -12 °C

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 0 °C

7: water; caesium carbonate / methanol / 2.5 h / 0 - 20 °C

8: toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 1.5 h

9: pyridine / dichloromethane / 2.5 h / 0 °C / Inert atmosphere

10: methanol / dichloromethane / 15 h

With pyridine; methanol; chlorosulfonic acid; oxalyl dichloride; 18-crown-6 ether; sulfuric acid; water; caesium carbonate; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium nitrate; N-ethyl-N,N-diisopropylamine; sodium iodide; In methanol; dichloromethane; N,N-dimethyl acetamide; acetic acid; N,N-dimethyl-formamide; butanone;
DOI:10.1021/jm201717y

Reference yield:

: 1363480-64-1
(3-(2,2,2-trifluoroacetyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl acetate

: 1363479-19-9
(7-(N-(2-hydroxyethyl)sulfamoyl)-3-(5-(2-morpholinoethoxy)-1H-indole-2-carbonyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate trifluoroacetate

Guidance literature:: Multi-step reaction with 8 steps

1: chlorosulfonic acid / dichloromethane / -80 - 5 °C

2: oxalyl dichloride / N,N-dimethyl-formamide / 3 h / -10 - 5 °C

3: sulfuric acid; potassium nitrate / 0.25 h / -12 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 0 °C

5: water; caesium carbonate / methanol / 2.5 h / 0 - 20 °C

6: toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 1.5 h

7: pyridine / dichloromethane / 2.5 h / 0 °C / Inert atmosphere

8: methanol / dichloromethane / 15 h

With pyridine; methanol; chlorosulfonic acid; oxalyl dichloride; sulfuric acid; water; caesium carbonate; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium nitrate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm201717y

Reference yield:

: C₁₅H₁₅NO₂

: 1363479-19-9
(7-(N-(2-hydroxyethyl)sulfamoyl)-3-(5-(2-morpholinoethoxy)-1H-indole-2-carbonyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate trifluoroacetate

Guidance literature:: Multi-step reaction with 9 steps

1: pyridine / 0.25 h / 0 °C

2: chlorosulfonic acid / dichloromethane / -80 - 5 °C

3: oxalyl dichloride / N,N-dimethyl-formamide / 3 h / -10 - 5 °C

4: sulfuric acid; potassium nitrate / 0.25 h / -12 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 0 °C

6: water; caesium carbonate / methanol / 2.5 h / 0 - 20 °C

7: toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 1.5 h

8: pyridine / dichloromethane / 2.5 h / 0 °C / Inert atmosphere

9: methanol / dichloromethane / 15 h

With pyridine; methanol; chlorosulfonic acid; oxalyl dichloride; sulfuric acid; water; caesium carbonate; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium nitrate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm201717y