N-[(1R,2S)-3-[(4-Methoxy-phenyl)-diphenyl-methoxy]-2-(2-trimethylsilanyl-ethoxymethoxy)-1-(2-trimethylsilanyl-ethoxymethoxymethyl)-propyl]-acetamide

Base Information

Chemical Name:N-[(1R,2S)-3-[(4-Methoxy-phenyl)-diphenyl-methoxy]-2-(2-trimethylsilanyl-ethoxymethoxy)-1-(2-trimethylsilanyl-ethoxymethoxymethyl)-propyl]-acetamide
CAS No.:143517-04-8
Molecular Formula:C₃₈H₅₇NO₇Si₂
Molecular Weight:696.044
Hs Code.:

N-[(1R,2S)-3-[(4-Methoxy-phenyl)-diphenyl-methoxy]-2-(2-trimethylsilanyl-ethoxymethoxy)-1-(2-trimethylsilanyl-ethoxymethoxymethyl)-propyl]-acetamide

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Chemical Property of N-[(1R,2S)-3-[(4-Methoxy-phenyl)-diphenyl-methoxy]-2-(2-trimethylsilanyl-ethoxymethoxy)-1-(2-trimethylsilanyl-ethoxymethoxymethyl)-propyl]-acetamide

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Technology Process of N-[(1R,2S)-3-[(4-Methoxy-phenyl)-diphenyl-methoxy]-2-(2-trimethylsilanyl-ethoxymethoxy)-1-(2-trimethylsilanyl-ethoxymethoxymethyl)-propyl]-acetamide

There total 12 articles about N-[(1R,2S)-3-[(4-Methoxy-phenyl)-diphenyl-methoxy]-2-(2-trimethylsilanyl-ethoxymethoxy)-1-(2-trimethylsilanyl-ethoxymethoxymethyl)-propyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122885-62-5
4'-methoxytrityl-4-oxy-buten-2-en-1-ol

: 143517-04-8
N-[(1R,2S)-3-[(4-Methoxy-phenyl)-diphenyl-methoxy]-2-(2-trimethylsilanyl-ethoxymethoxy)-1-(2-trimethylsilanyl-ethoxymethoxymethyl)-propyl]-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) titanium tetraisopropoxide, diethyl D-(-)-tartrate, 2.) tert-butylhydroperoxide, 3.) aq. 10 percent tartaric acid

2: 83 percent / titanium tetraisopropoxide, trimethylsilyl azide / benzene / 0.5 h / 40 °C

3: 1.39 g / diisopropylethylamine / CH₂Cl₂ / 5 h / 40 °C

4: 1.3 g / lithium aluminum hydride / tetrahydrofuran / 0.5 h / Ambient temperature

5: 1.54 g / pyridine / 2 h / Ambient temperature

With pyridine; titanium(IV) isopropylate; tert.-butylhydroperoxide; lithium aluminium tetrahydride; diethyl (2S,3S)-tartrate; trimethylsilylazide; tartaric acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1248/cpb.40.1154

Reference yield:

: 143516-84-1
Propionic acid (Z)-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-but-2-enyl ester

: 143517-04-8
N-[(1R,2S)-3-[(4-Methoxy-phenyl)-diphenyl-methoxy]-2-(2-trimethylsilanyl-ethoxymethoxy)-1-(2-trimethylsilanyl-ethoxymethoxymethyl)-propyl]-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: 10 percent KOH-MeOH / 0.5 h / Ambient temperature

2: 1.) titanium tetraisopropoxide, diethyl D-(-)-tartrate, 2.) tert-butylhydroperoxide, 3.) aq. 10 percent tartaric acid

3: 83 percent / titanium tetraisopropoxide, trimethylsilyl azide / benzene / 0.5 h / 40 °C

4: 1.39 g / diisopropylethylamine / CH₂Cl₂ / 5 h / 40 °C

5: 1.3 g / lithium aluminum hydride / tetrahydrofuran / 0.5 h / Ambient temperature

6: 1.54 g / pyridine / 2 h / Ambient temperature

With pyridine; titanium(IV) isopropylate; tert.-butylhydroperoxide; potassium hydroxide; lithium aluminium tetrahydride; diethyl (2S,3S)-tartrate; trimethylsilylazide; tartaric acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1248/cpb.40.1154

Reference yield:

: 143615-64-9
{(2S,3R)-3-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-oxiranyl}-methanol

: 143517-04-8
N-[(1R,2S)-3-[(4-Methoxy-phenyl)-diphenyl-methoxy]-2-(2-trimethylsilanyl-ethoxymethoxy)-1-(2-trimethylsilanyl-ethoxymethoxymethyl)-propyl]-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / titanium tetraisopropoxide, trimethylsilyl azide / benzene / 0.5 h / 40 °C

2: 1.39 g / diisopropylethylamine / CH₂Cl₂ / 5 h / 40 °C

3: 1.3 g / lithium aluminum hydride / tetrahydrofuran / 0.5 h / Ambient temperature

4: 1.54 g / pyridine / 2 h / Ambient temperature

With pyridine; titanium(IV) isopropylate; lithium aluminium tetrahydride; trimethylsilylazide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1248/cpb.40.1154