(S)-C-cyclopropyl-C-(3-ethanesulfonylphenyl)methylamine

Base Information

• Chemical Name: (S)-C-cyclopropyl-C-(3-ethanesulfonylphenyl)methylamine
• CAS No.: 1414778-82-7
• Molecular Formula: C₁₂H₁₇NO₂S
• Molecular Weight: 239.338
• Mol file: 1414778-82-7.mol

Synonyms:

Chemical Property of (S)-C-cyclopropyl-C-(3-ethanesulfonylphenyl)methylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-C-cyclopropyl-C-(3-ethanesulfonylphenyl)methylamine

There total 6 articles about (S)-C-cyclopropyl-C-(3-ethanesulfonylphenyl)methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-ethylthiobenzaldehyde → (R)-C-cyclopropyl-C-(3-ethanesulfonylphenyl)methylamine (1414778-83-8) + (S)-C-cyclopropyl-C-(3-ethanesulfonylphenyl)methylamine (1414778-82-7)

Guidance literature:

Multi-step reaction with 5 steps

1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: 3-chloro-benzenecarboperoxoic acid / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: diphenylphosphoranyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 0 - 80 °C / Inert atmosphere

4: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C

5: Chiralpak AY-H / ethanol; n-heptane; diethylamine / Resolution of racemate

With diphenylphosphoranyl azide; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; n-heptane; diethylamine; toluene;

Reference yield:

cyclopropyl[3-(ethylsulfanyl)phenyl]methanol (1414778-46-3) → (R)-C-cyclopropyl-C-(3-ethanesulfonylphenyl)methylamine (1414778-83-8) + (S)-C-cyclopropyl-C-(3-ethanesulfonylphenyl)methylamine (1414778-82-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 3-chloro-benzenecarboperoxoic acid / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: diphenylphosphoranyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 0 - 80 °C / Inert atmosphere

3: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C

4: Chiralpak AY-H / ethanol; n-heptane; diethylamine / Resolution of racemate

With diphenylphosphoranyl azide; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; n-heptane; diethylamine; toluene;

Reference yield:

cyclopropyl[3-(ethylsulfonyl)phenyl]methanol (1414778-48-5) → (R)-C-cyclopropyl-C-(3-ethanesulfonylphenyl)methylamine (1414778-83-8) + (S)-C-cyclopropyl-C-(3-ethanesulfonylphenyl)methylamine (1414778-82-7)

Guidance literature:

Multi-step reaction with 3 steps

1: diphenylphosphoranyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 0 - 80 °C / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C

3: Chiralpak AY-H / ethanol; n-heptane; diethylamine / Resolution of racemate

With diphenylphosphoranyl azide; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium 10% on activated carbon; In methanol; ethanol; n-heptane; diethylamine; toluene;

upstream raw materials:

3-bromo-1-ethanesulfanylbenzene

C-cyclopropyl-C-(3-ethanesulfonylphenyl)methylamine

cyclopropyl[3-(ethylsulfanyl)phenyl]methanol

cyclopropyl[3-(ethylsulfonyl)phenyl]methanol