Technology Process of 5-[4-(2-phenylethyl)-1H-1,2,3-triazol-1-yl]-1H-indazole
There total 4 articles about 5-[4-(2-phenylethyl)-1H-1,2,3-triazol-1-yl]-1H-indazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium azide; copper(ll) sulfate pentahydrate; sodium carbonate; sodium L-ascorbate; L-proline;
In
dimethyl sulfoxide;
at 65 ℃;
DOI:10.1016/j.bmcl.2011.01.007
- Guidance literature:
-
Multi-step reaction with 3 steps
1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 95 °C
2: methanol; potassium hydroxide
3: copper(ll) sulfate pentahydrate; sodium azide; sodium carbonate; sodium L-ascorbate; L-proline / dimethyl sulfoxide / 65 °C
With
methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium azide; copper(ll) sulfate pentahydrate; sodium carbonate; sodium L-ascorbate; triethylamine; L-proline; potassium hydroxide;
In
dimethyl sulfoxide; N,N-dimethyl-formamide;
1: Sonogashira coupling;
DOI:10.1016/j.bmcl.2011.01.007
- Guidance literature:
-
Multi-step reaction with 4 steps
1: dmap / dichloromethane / 20 °C
2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 95 °C
3: methanol; potassium hydroxide
4: copper(ll) sulfate pentahydrate; sodium azide; sodium carbonate; sodium L-ascorbate; L-proline / dimethyl sulfoxide / 65 °C
With
methanol; dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium azide; copper(ll) sulfate pentahydrate; sodium carbonate; sodium L-ascorbate; triethylamine; L-proline; potassium hydroxide;
In
dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
2: Sonogashira coupling;
DOI:10.1016/j.bmcl.2011.01.007
