1,2,3,4,4a,5,6,7-octahydro-2,2,4a,7,7-pentametyl-1,8-naphthyridene

Base Information

• Chemical Name: 1,2,3,4,4a,5,6,7-octahydro-2,2,4a,7,7-pentametyl-1,8-naphthyridene
• CAS No.: 308280-56-0
• Molecular Formula: C₁₃H₂₄N₂
• Molecular Weight: 208.347
• Mol file: 308280-56-0.mol

Synonyms:

Chemical Property of 1,2,3,4,4a,5,6,7-octahydro-2,2,4a,7,7-pentametyl-1,8-naphthyridene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2,3,4,4a,5,6,7-octahydro-2,2,4a,7,7-pentametyl-1,8-naphthyridene

There total 4 articles about 1,2,3,4,4a,5,6,7-octahydro-2,2,4a,7,7-pentametyl-1,8-naphthyridene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-Cyano-2,5,8-trimethylnona-2,7-diene (69340-56-3) → 1,2,3,4,4a,5,6,7-octahydro-2,2,4a,7,7-pentametyl-1,8-naphthyridene (69340-58-5,308280-56-0,1212823-64-7)

Guidance literature:

Multi-step reaction with 2 steps

1: NaNH₂ / benzene; toluene / 8 h / Heating

2: 1) gaseous HCl / 1) CH₂Cl₂, 0 deg C, 2) 200 deg C

With hydrogenchloride; sodium amide; In toluene; benzene;

Reference yield:

5-Amidino-2,5,8-trimethylnona-2,7-diene (69340-57-4) → 1,2,3,4,4a,5,6,7-octahydro-2,2,4a,7,7-pentametyl-1,8-naphthyridene (69340-58-5,308280-56-0,1212823-64-7)

Guidance literature:

With hydrogenchloride; Multistep reaction; 1) CH₂Cl₂, 0 deg C, 2) 200 deg C;

Reference yield:

2,2,4a,7,7-pentamethyl-1,2,3,4,4a,5,6,7-octahydro-[1,8]naphthyridine; compound with carbonic acid → 1,2,3,4,4a,5,6,7-octahydro-2,2,4a,7,7-pentametyl-1,8-naphthyridene (69340-58-5,308280-56-0,1212823-64-7)

Guidance literature:

at 122 ℃;

DOI:10.1039/c1gc15457e

upstream raw materials:

5-Amidino-2,5,8-trimethylnona-2,7-diene

5-Cyano-2,5,8-trimethylnona-2,7-diene

Downstream raw materials:

2,2,4a,7,7-Pentamethyl-1,2,3,4,4a,5,6,7-octahydro-[1,8]naphthyridine; compound with (2R,5R)-3,3-dimethyl-7-oxo-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid

(3R,5S)-3-Hydroxy-4,4-dimethyl-7-oxo-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid; compound with 2,2,4a,7,7-pentamethyl-1,2,3,4,4a,5,6,7-octahydro-[1,8]naphthyridine

(3S,4R)-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-oxo-1-sulfoazetidinone 3,3,6,9,9-pentamethyl-2,10-diazabicyclo<4.4.0>-1-decene salt

(3R,4S)-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-oxo-1-sulfoazetidinone 3,3,6,9,9-pentamethyl-2,10-diazabicyclo<4.4.0>-1-decene salt