Benzenepentanoic acid, b-amino-, ethyl ester

Base Information

• Chemical Name: Benzenepentanoic acid, b-amino-, ethyl ester
• CAS No.: 134420-70-5
• Molecular Formula: C13H19NO2
• Molecular Weight: 221.299
• Mol file: 134420-70-5.mol

Synonyms:

Chemical Property of Benzenepentanoic acid, b-amino-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenepentanoic acid, b-amino-, ethyl ester

There total 4 articles about Benzenepentanoic acid, b-amino-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

3-dibenzylamino-5-phenyl-pent-4-ynoic acid ethyl ester (1161747-24-5) → 3-amino-5-phenyl-pentanoic acid ethyl ester (134420-70-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 24h; under 750.075 Torr;

DOI:10.1002/adsc.200800447

Reference yield:

ethyl 3-amino-5-phenylpent-2-enoate (247242-35-9) → 3-amino-5-phenyl-pentanoic acid ethyl ester (134420-70-5)

Guidance literature:

With sodium tris(acetoxy)borohydride; In acetic acid; at 20 ℃; for 3h;

DOI:10.1016/S0040-4020(02)00730-5

Reference yield:

ethyl 3-amino-3-(phenethyl)-propionate hydrochloride → 3-amino-5-phenyl-pentanoic acid ethyl ester (134420-70-5)

Guidance literature:

With potassium carbonate; In water;

DOI:10.1039/b920731g

upstream raw materials:

ethyl 3-amino-5-phenylpent-2-enoate

ethyl 3-oxo-5-phenylpentanoate

3-dibenzylamino-5-phenyl-pent-4-ynoic acid ethyl ester

Downstream raw materials:

ethyl N-(2-carbethoxyethyl)-3-amino-5-phenylvalerate

(S)-3-amino-5-phenylpentanoic acid

(3R)-3-amino-5-phenylpentanoic acid

6-phenethylguvacine hydrochloride

Refernces

• 1、 Zhou, Lei,Shuai, Qi,Jiang, Huan-Feng,Li, Chao-Jun. "Copper-catalyzed amine-alkyne-alkyne addition reaction: An efficient method for the synthesis of γ,δ-alkynyl-β-amino acid derivatives". scheme or table. p. 11668 - 11674. Retrieved 2010/04/28.
• 2、 Prévost, Natacha,Shipman, Michael. "Synthesis of substituted piperidines, decahydroquinolines and octahydroindolizines by radical rearrangement reactions of 2-alkylideneaziridines". . p. 7165 - 7175. Retrieved 2007/10/03.