1-(cyclohexyl-[2H,2H]-methoxy)-3-diazopropanone

Base Information

• Chemical Name: 1-(cyclohexyl-[2H,2H]-methoxy)-3-diazopropanone
• CAS No.: 372142-95-5
• Molecular Formula: C₁₀H₁₆N₂O₂
• Molecular Weight: 198.233
• Mol file: 372142-95-5.mol

Synonyms:

Chemical Property of 1-(cyclohexyl-[2H,2H]-methoxy)-3-diazopropanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(cyclohexyl-[2H,2H]-methoxy)-3-diazopropanone

There total 5 articles about 1-(cyclohexyl-[2H,2H]-methoxy)-3-diazopropanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl cyclohexylcarboxylate (4630-82-4) → 1-(cyclohexyl-[2H,2H]-methoxy)-3-diazopropanone (372142-95-5)

Guidance literature:

Multi-step reaction with 5 steps

1: LiAlD₄

2: rhodiummcatalyst / CH₂Cl₂ / 0.33 h

3: 80 percent / aq. LiOH / tetrahydrofuran / 1.5 h / Heating

4: oxalyl chloride; DMF / CH₂Cl₂; diethyl ether / 2 h / 20 °C

5: 658 mg / CH₂Cl₂; diethyl ether / 2 h / 4 °C

With lithium hydroxide; lithium aluminium deuteride; oxalyl dichloride; N,N-dimethyl-formamide; rhodiummcatalyst; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1021/jo049900e

Reference yield:

cyclohexane-1,1-[2H,2H]-methanol (467238-80-8) → 1-(cyclohexyl-[2H,2H]-methoxy)-3-diazopropanone (372142-95-5)

Guidance literature:

Multi-step reaction with 4 steps

1: rhodiummcatalyst / CH₂Cl₂ / 0.33 h

2: 80 percent / aq. LiOH / tetrahydrofuran / 1.5 h / Heating

3: oxalyl chloride; DMF / CH₂Cl₂; diethyl ether / 2 h / 20 °C

4: 658 mg / CH₂Cl₂; diethyl ether / 2 h / 4 °C

With lithium hydroxide; oxalyl dichloride; N,N-dimethyl-formamide; rhodiummcatalyst; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1021/jo049900e

Reference yield:

(cyclohexyl-[2H,2H]-methoxy)acetic acid (711603-98-4) → 1-(cyclohexyl-[2H,2H]-methoxy)-3-diazopropanone (372142-95-5)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride; DMF / CH₂Cl₂; diethyl ether / 2 h / 20 °C

2: 658 mg / CH₂Cl₂; diethyl ether / 2 h / 4 °C

With oxalyl dichloride; N,N-dimethyl-formamide; In diethyl ether; dichloromethane;

DOI:10.1021/jo049900e

upstream raw materials:

diazomethane

methyl cyclohexylcarboxylate

cyclohexane-1,1-[2H,2H]-methanol

(cyclohexyl-[2H,2H]-methoxy)acetic acid