Technology Process of 1,8-decadiyne
There total 2 articles about 1,8-decadiyne which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper; zinc;
In
diethyl ether;
for 15h;
Heating;
- Guidance literature:
-
Multistep reaction. Title compound not separated from byproducts;
(i) Na, (ii) /BRN= 635994/;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 1.5 h / -78 °C / Inert atmosphere
1.2: 0.33 h / -78 °C / Inert atmosphere
1.3: 3.58 h / -78 °C / Inert atmosphere
2.1: sodium; ammonia / tetrahydrofuran; tert-butyl alcohol / 1 h / -40 °C / Inert atmosphere
3.1: Dess-Martin periodane / dichloromethane / 0.17 h / 20 °C / Inert atmosphere
4.1: tert.-butyl lithium / tetrahydrofuran; pentane / 1.5 h / -25 °C / Inert atmosphere
4.2: 0.33 h / -78 °C / Inert atmosphere
5.1: bis-[(trifluoroacetoxy)iodo]benzene / methanol; water / 0.08 h / Inert atmosphere
6.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.5 h / Inert atmosphere
7.1: caesium carbonate / acetone / 4 h / Inert atmosphere; Reflux
With
n-butyllithium; carbon tetrabromide; ammonia; tert.-butyl lithium; sodium; caesium carbonate; Dess-Martin periodane; triphenylphosphine; bis-[(trifluoroacetoxy)iodo]benzene;
In
tetrahydrofuran; methanol; hexane; dichloromethane; water; acetone; tert-butyl alcohol; pentane;
DOI:10.1021/jo302353g
