D-3-Methylaspartic acid

Base Information

• Chemical Name: D-3-Methylaspartic acid
• CAS No.: 43176-54-1
• Molecular Formula: C₅H₉NO₄
• Molecular Weight: 148.12
• Mol file: 43176-54-1.mol

Synonyms:

Chemical Property of D-3-Methylaspartic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

(R)-2-Amino-3-methylsuccinicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of D-3-Methylaspartic acid

There total 3 articles about D-3-Methylaspartic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

[13C]mesaconic acid (43176-53-0) → [5-13C]-(2S,3S)-3-methylaspartic acid (43176-54-1)

Guidance literature:

With β-methyl aspartase; potassium chloride; ammonium chloride; magnesium chloride; In water; at 32 ℃; pH=9;

DOI:10.1002/ejoc.200300410

Reference yield:

diethylitaconate (2409-52-1) → [5-13C]-(2S,3S)-3-methylaspartic acid (43176-54-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: DBU / toluene / Heating

1.2: 81 percent / aq. HCl / 3 h / Heating

2.1: 92 percent / β-methyl aspartase; NH4Cl; KCl / MgCl2*6H2O / H2O / 32 °C / pH 9

With β-methyl aspartase; potassium chloride; ammonium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; magnesium chloride; In water; toluene;

DOI:10.1002/ejoc.200300410

Reference yield:

→ [5-13C]-(2S,3S)-3-methylaspartic acid (43176-54-1)

Guidance literature:

/BRN= 45052/, NH3;

DOI:10.1021/ja00799a070

upstream raw materials:

[13C]mesaconic acid

diethylitaconate