tert-butyl 4-mercaptopiperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-mercaptopiperidine-1-carboxylate
• CAS No.: 134464-79-2
• Molecular Formula: C10H19NO2S
• Molecular Weight: 217.332
• Hs Code.: 2933399090
• Mol file: 134464-79-2.mol

Synonyms:1-Piperidinecarboxylic acid,4-mercapto-,1,1-dimethylethyl ester;tert-Butyl 4-mercaptopiperidine-1-carboxylate;tert-butyl 4-sulfanylpiperidin-1-carboxylate;1-(tert-butoxycarbonyl)-4-mercaptopiperidine;1-t-Butoxycarbonyl-4-mercaptopiperidine;1-(tert-butyloxycarbonyl)-4-mercapto-piperidine;1-Boc-4-mercapto-piperidine;4-Mercapto-piperidine-1-carboxylic acid tert-butyl ester;tert-butyl 4-mercapto-1-piperidinecarboxylate;1-N-Boc-4-Mercaptopiperidine;

Chemical Property of tert-butyl 4-mercaptopiperidine-1-carboxylate

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Boiling Point: 294.23oC at 760 mmHg
• PKA: 10.52±0.20(Predicted)
• Flash Point: 131.746oC
• PSA: 68.34000
• Density: 1.083g/cm3
• LogP: 2.25360

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-Mercaptopiperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 4-mercaptopiperidine-1-carboxylate

There total 9 articles about tert-butyl 4-mercaptopiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-tert-Butyloxycarbonyl-4-(acetylsulfanyl)piperidine (141699-66-3) → tert-butyl 4-mercapto-1-piperidinecarboxylate (134464-79-2)

Guidance literature:

With methanol; sodium methylate; at 0 - 20 ℃; for 5h;

Reference yield: 76.0%

di-tert-butyl 4,4’-disulfanediyldipiperidine-1-carboxylate → tert-butyl 4-mercapto-1-piperidinecarboxylate (134464-79-2)

Guidance literature:

With acetic acid; zinc; at 60 ℃; for 16h;

Reference yield: 53.0%

tert-butyl 4-sulfanylidenepiperidin-1-carboxylate (1373131-17-9) → tert-butyl 4-mercapto-1-piperidinecarboxylate (134464-79-2)

Guidance literature:

With sodium tetrahydroborate; ethanol; at 0 - 80 ℃; for 2.33333h; Inert atmosphere;

upstream raw materials:

1-tert-Butyloxycarbonyl-4-(acetylsulfanyl)piperidine

N-tert-butyloxycarbonylpiperidin-4-one

tert-butyl 4-sulfanylidenepiperidin-1-carboxylate

4-(4-nitrophenylsulfanyl)piperidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

tert-butyl 4-(1-(4-methoxybenzyl)-4-(4-amino-2-fluorophenoxy)-1H-pyrazolo[3,4-b]pyridin-3-ylthio)piperidine-1-carboxylate

tert-butyl 4-(pyridin-2-ylthio)piperidine-1-carboxylate

tert-butyl 4-(benzylsulfanyl)piperidine-1-carboxylate