JAK3-IN-1

Base Information

Chemical Name:JAK3-IN-1
CAS No.:1805787-93-2
Molecular Formula:C₂₆H₃₀ClN₇O₂
Molecular Weight:508.023
Hs Code.:
Mol file:1805787-93-2.mol

Synonyms:

Suppliers and Price of JAK3-IN-1

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
JAK3-IN-1 98+%
5mg
$ 243.00

Crysdot
JAK3-IN-1 98+%
100mg
$ 1459.00

Crysdot
JAK3-IN-1 98+%
50mg
$ 1042.00

ChemScene
JAK3-IN-1 99.98%
10mg
$ 600.00

ChemScene
JAK3-IN-1 99.98%
5mg
$ 420.00

ChemScene
JAK3-IN-1 99.98%
50mg
$ 1800.00

ChemScene
JAK3-IN-1 99.98%
100mg
$ 2520.00

Biorbyt Ltd
JAK3-IN-1
100 mg
$ 2512.60

Biorbyt Ltd
JAK3-IN-1
50 mg
$ 1802.00

Biorbyt Ltd
JAK3-IN-1
10 mg
$ 615.40

Total 4 raw suppliers

Chemical Property of JAK3-IN-1

Chemical Property:

PKA:13.48±0.70(Predicted)
Density:1.315±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

JAK3-IN-1 98+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of JAK3-IN-1

There total 3 articles about JAK3-IN-1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₂₈ClN₇O

: 814-68-6,25189-84-8
acryloyl chloride

: 1805787-93-2
N-(3-(((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)methyl)phenyl)acrylamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at -60 - 20 ℃; for 0.666667h;
DOI:10.1021/acs.jmedchem.5b00710

Reference yield:

: 2,5-dichloro-N-(3-nitrobenzyl)pyrimidin-4-amine

: 1805787-93-2
N-(3-(((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)methyl)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / iso-butanol / 100 °C

2: hydrogen / methanol / 3 h / 760.05 Torr

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.67 h / -60 - 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; N,N-dimethyl-formamide; iso-butanol;
DOI:10.1021/acs.jmedchem.5b00710

Reference yield:

: 26177-43-5
3-nitrobenzylamine hydrochloride

: 1805787-93-2
N-(3-(((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)methyl)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 20 °C

2: trifluoroacetic acid / iso-butanol / 100 °C

3: hydrogen / methanol / 3 h / 760.05 Torr

4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.67 h / -60 - 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; iso-butanol;
DOI:10.1021/acs.jmedchem.5b00710