5-(4-Aminoimidazo[4,5-d]triazin-7-yl)-2-(hydroxymethyl)oxolan-3-ol

Base Information

• Chemical Name: 5-(4-Aminoimidazo[4,5-d]triazin-7-yl)-2-(hydroxymethyl)oxolan-3-ol
• CAS No.: 34536-05-5
• Molecular Formula: C9H12 N6 O3
• Molecular Weight: 252.23
• NSC Number: 134699
• Mol file: 34536-05-5.mol

Synonyms:34536-05-5;NSC134699;SCHEMBL21625245;NSC-134699

Chemical Property of 5-(4-Aminoimidazo[4,5-d]triazin-7-yl)-2-(hydroxymethyl)oxolan-3-ol

Chemical Property:

• Vapor Pressure: 2E-19mmHg at 25°C
• Boiling Point: 680.1°C at 760 mmHg
• Flash Point: 365.1°C
• Density: 2.11g/cm³
• XLogP3: -1.5
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 2
• Exact Mass: 252.09708827
• Heavy Atom Count: 18
• Complexity: 308

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(C(OC1N2C=NC3=C(N=NN=C32)N)CO)O

Technology Process of 5-(4-Aminoimidazo[4,5-d]triazin-7-yl)-2-(hydroxymethyl)oxolan-3-ol

There total 8 articles about 5-(4-Aminoimidazo[4,5-d]triazin-7-yl)-2-(hydroxymethyl)oxolan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

3-(2-Deoxy-β-D-erythro-pentafuranosyl)-1H-diimidazo[1,2-c:4',5'-e][1,2,3]triazine (261776-85-6) → 4-Amino-7-(2-deoxy-β-D-erythro-pentafuranosyl)-7H-imidazo[4,5-d][1,2,3]triazine (34536-05-5)

Guidance literature:

With N-Bromosuccinimide; NaOAc buffer; at 20 ℃; pH=4.0 - 4.5;

DOI:10.1002/(SICI)1521-3765(20000117)6:2<369::AID-CHEM369>3.0.CO;2-2

Reference yield: 26.0%

7-<2'-Deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-4-(methylthio)-7H-imidazo<4,5-d>-1,2,3-triazine (126754-82-3) → 4-Amino-7-(2-deoxy-β-D-erythro-pentafuranosyl)-7H-imidazo[4,5-d][1,2,3]triazine (34536-05-5)

Guidance literature:

With ammonia; In methanol; at 70 - 75 ℃; for 48h;

Reference yield:

3-(2-Deoxy-β-D-erythro-pentafuranosyl)-3H-imidazo[2,1-i]purine (68498-25-9) → 4-Amino-7-(2-deoxy-β-D-erythro-pentafuranosyl)-7H-imidazo[4,5-d][1,2,3]triazine (34536-05-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent / aq. NaOH / 20 °C

2: 53 percent / aq. AcOH; NaNO₂ / 1 h

3: 38 percent / NBS; aq. NaOAc buffer / 20 °C / pH 4.0 - 4.5

With sodium hydroxide; N-Bromosuccinimide; NaOAc buffer; acetic acid; sodium nitrite; 1: Ring cleavage / 2: Diazotization / 3: Ring cleavage;

DOI:10.1002/(SICI)1521-3765(20000117)6:2<369::AID-CHEM369>3.0.CO;2-2

upstream raw materials:

7-<2'-Deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-4-(methylthio)-7H-imidazo<4,5-d>-1,2,3-triazine

2'-deoxyuridine

2-azaadenine

3-(2-Deoxy-β-D-erythro-pentafuranosyl)-1H-diimidazo[1,2-c:4',5'-e][1,2,3]triazine

Downstream raw materials:

7-(2-Deoxy-β-D-erythro-pentafuranosyl)-7H-imidazo[4,5-d][1,2,3]triazin-4-one

7-[2-Deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythro-pentofuranosyl]-4-{[(di-n-butylamino)methylidene]amino}-7H-imidazo[4,5-d][1,2,3]triazine