(2RS,3SR)-3-hydroxy-2-methyl-3-phenylpropionamide

Base Information

• Chemical Name: (2RS,3SR)-3-hydroxy-2-methyl-3-phenylpropionamide
• CAS No.: 29478-51-1
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.219
• Mol file: 29478-51-1.mol

Synonyms:

Chemical Property of (2RS,3SR)-3-hydroxy-2-methyl-3-phenylpropionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2RS,3SR)-3-hydroxy-2-methyl-3-phenylpropionamide

There total 15 articles about (2RS,3SR)-3-hydroxy-2-methyl-3-phenylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(2RS,3RS)-3-fluoro(dimethyl)silyl-2-methyl-3-phenylpropionamide → (2RS,3SR)-3-hydroxy-2-methyl-3-phenylpropionamide (29478-51-1,29478-52-2,99075-48-6)

Guidance literature:

With potassium fluoride; 3-chloro-benzenecarboperoxoic acid; In N,N-dimethyl-formamide; for 4h; Ambient temperature;

Reference yield: 39.0%

2-methyl-3-oxo-3-phenylpropanenitrile (7391-29-9) → (2RS,3SR)-3-hydroxy-2-methyl-3-phenylpropionamide (29478-51-1,29478-52-2,99075-48-6) + 3-hydroxy-2-methyl-3-phenylpropanamide

Guidance literature:

With [RuCl₂(η⁶-p-cymene)(P(4-C₆H₄F)₂Cl)]; sodium formate; In water; at 100 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.1016/j.jorganchem.2019.05.016

Reference yield:

(2S*,3S*)-3-hydroxy-2-methyl-3-phenylpropanenitrile → (2RS,3SR)-3-hydroxy-2-methyl-3-phenylpropionamide (29478-51-1,29478-52-2,99075-48-6)

Guidance literature:

With sodium hydroxide; dihydrogen peroxide; In methanol; at 45 ℃;

upstream raw materials:

3-hydroxy-3-phenyl-2-methylpropionitrile

2-methyl-3-oxo-3-phenylpropionic acid

2-methyl-3-oxo-3-phenyl-propionic acid amide

methyl 3-hydroxy-2-methyl-3-phenylpropanoate

Downstream raw materials:

5r-methyl-6t-phenyl-[1,3]oxazinan-2-one

anti-3-hydroxy-2-methyl-3-phenylpropanylamine