(N₄,3S)-dihydroxy-N₁-[(1S)-2,2-dimethyl-1-({[(1S)-2-hydroxy-1-phenylethyl]amino}carbonyl)propyl]-(2R)-2-{3-[3-methyl-(4-phenyl)phenyl]propyl}butanediamide

Base Information

• Chemical Name: (N₄,3S)-dihydroxy-N₁-[(1S)-2,2-dimethyl-1-({[(1S)-2-hydroxy-1-phenylethyl]amino}carbonyl)propyl]-(2R)-2-{3-[3-methyl-(4-phenyl)phenyl]propyl}butanediamide
• CAS No.: 230961-37-2
• Molecular Formula: C₃₄H₄₃N₃O₆
• Molecular Weight: 589.732

Synonyms:

Chemical Property of (N₄,3S)-dihydroxy-N₁-[(1S)-2,2-dimethyl-1-({[(1S)-2-hydroxy-1-phenylethyl]amino}carbonyl)propyl]-(2R)-2-{3-[3-methyl-(4-phenyl)phenyl]propyl}butanediamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (N₄,3S)-dihydroxy-N₁-[(1S)-2,2-dimethyl-1-({[(1S)-2-hydroxy-1-phenylethyl]amino}carbonyl)propyl]-(2R)-2-{3-[3-methyl-(4-phenyl)phenyl]propyl}butanediamide

There total 11 articles about (N₄,3S)-dihydroxy-N₁-[(1S)-2,2-dimethyl-1-({[(1S)-2-hydroxy-1-phenylethyl]amino}carbonyl)propyl]-(2R)-2-{3-[3-methyl-(4-phenyl)phenyl]propyl}butanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

(2R)-2-[(4S)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]-N-[(1S)-2,2-dimethyl-1-({[(1S)-2-hydroxy-1-phenylethyl]amino}carbonyl)propyl]-5-[(3-methyl-4-phenyl)phenyl]pentanamide → (N4,3S)-dihydroxy-N1-[(1S)-2,2-dimethyl-1-({[(1S)-2-hydroxy-1-phenylethyl]amino}carbonyl)propyl]-(2R)-2-{3-[3-methyl-(4-phenyl)phenyl]propyl}butanediamide (230961-37-2)

Guidance literature:

With hydroxylamine; at 20 ℃; for 17h;

Reference yield:

(2R)-N-{(1S)-1-[(benzyloxy)carbonyl]-2,2-dimethylpropyl}-2-[(4S)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]pent-4-enamide (230962-55-7) → (N4,3S)-dihydroxy-N1-[(1S)-2,2-dimethyl-1-({[(1S)-2-hydroxy-1-phenylethyl]amino}carbonyl)propyl]-(2R)-2-{3-[3-methyl-(4-phenyl)phenyl]propyl}butanediamide (230961-37-2)

Guidance literature:

Multi-step reaction with 4 steps

1: N-ethylmorpholine; / palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 15 h / Heating / reflux

2: hydrogen / palladium 10% on activated carbon / ethanol / 6 h / 20 °C / 2250.23 Torr

3: 3 h / 20 °C

4: hydroxylamine / 17 h / 20 °C

With N-ethylmorpholine;; hydrogen; hydroxylamine; palladium 10% on activated carbon; palladium diacetate; tris-(o-tolyl)phosphine; In ethanol; acetonitrile;

Reference yield:

(2R,4E)-N-{(1S)-1-[(benzyloxy)carbonyl]-2,2-dimethylpropyl}-2-[(4S)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]-5-[(3-methyl-4-phenyl)phenyl]pent-4-enamide → (N4,3S)-dihydroxy-N1-[(1S)-2,2-dimethyl-1-({[(1S)-2-hydroxy-1-phenylethyl]amino}carbonyl)propyl]-(2R)-2-{3-[3-methyl-(4-phenyl)phenyl]propyl}butanediamide (230961-37-2)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 6 h / 20 °C / 2250.23 Torr

2: 3 h / 20 °C

3: hydroxylamine / 17 h / 20 °C

With hydrogen; hydroxylamine; palladium 10% on activated carbon; In ethanol;

upstream raw materials:

(2R)-N-{(1S)-1-[(benzyloxy)carbonyl]-2,2-dimethylpropyl}-2-[(4S)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]pent-4-enamide

(2R)-N-[(1S)-1-(carboxy)-2,2-dimethylpropyl]-2-[(4S)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]-5-[(3-methyl-4-phenyl)phenyl]pentanamide

2-bromo-5-nitrotoluene

2-methyl-4-nitrobiphenyl

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