2-amino-5-[(4-chlorophenyl)thio]-4-morpholinopyrimidine

Base Information

Chemical Name:2-amino-5-[(4-chlorophenyl)thio]-4-morpholinopyrimidine
CAS No.:93864-11-0
Molecular Formula:C₁₄H₁₅ClN₄OS
Molecular Weight:322.818
Hs Code.:

Synonyms:

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Chemical Property of 2-amino-5-[(4-chlorophenyl)thio]-4-morpholinopyrimidine

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Technology Process of 2-amino-5-[(4-chlorophenyl)thio]-4-morpholinopyrimidine

There total 4 articles about 2-amino-5-[(4-chlorophenyl)thio]-4-morpholinopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 106-54-7
p-Chlorothiophenol

: 93864-11-0
2-amino-5-[(4-chlorophenyl)thio]-4-morpholinopyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 92 percent / K₂CO₃ / dimethylformamide / 4 h / 110 °C

2.1: SOCl₂

3.1: ethanol / 2.5 h / 20 °C

3.2: 40 percent / 1M aq. NaOH / ethanol / 1 h / Heating

With thionyl chloride; potassium carbonate; In ethanol; N,N-dimethyl-formamide; 1.1: Substitution / 2.1: Condensation / 3.1: Substitution / 3.2: Hydrolysis;
DOI:10.1002/jhet.5570370131

Reference yield:

: 90799-83-0
2-amino-5-[(4-chlorophenyl)thio]-4(3H)-pyrimidone

: 93864-11-0
2-amino-5-[(4-chlorophenyl)thio]-4-morpholinopyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: SOCl₂

2.1: ethanol / 2.5 h / 20 °C

2.2: 40 percent / 1M aq. NaOH / ethanol / 1 h / Heating

With thionyl chloride; In ethanol; 1.1: Condensation / 2.1: Substitution / 2.2: Hydrolysis;
DOI:10.1002/jhet.5570370131

Reference yield:

: N'-[4-chloro-5-(4-chloro-phenylsulfanyl)-pyrimidin-2-yl]-N,N-dimethyl-formamidine

: 93864-11-0
2-amino-5-[(4-chlorophenyl)thio]-4-morpholinopyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl chloride / CH₂Cl₂ / 0.5 h / 20 °C

1.2: CH₂Cl₂ / 2 h / Heating

2.1: ethanol / 1 h / Heating

2.2: 74 percent / 1M aq. NaOH / ethanol / 1 h / Heating

With oxalyl dichloride; In ethanol; dichloromethane; 1.1: Condensation / 1.2: Substitution / 2.1: Substitution / 2.2: Hydrolysis;
DOI:10.1002/jhet.5570370131