(+)-1-<(p-tolyl-(R)-sulfinyl)acetyl>-cis-2,3,4,4a(S),5(S),6,7,11c(R)-octahydro-5α(R)-chloro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole

Base Information

Chemical Name:(+)-1-<(p-tolyl-(R)-sulfinyl)acetyl>-cis-2,3,4,4a(S),5(S),6,7,11c(R)-octahydro-5α(R)-chloro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole
CAS No.:89063-46-7
Molecular Formula:C₃₁H₃₁ClN₂O₅S₂
Molecular Weight:611.183
Hs Code.:

Synonyms:

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Chemical Property of (+)-1-<(p-tolyl-(R)-sulfinyl)acetyl>-cis-2,3,4,4a(S),5(S),6,7,11c(R)-octahydro-5α(R)-chloro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole

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Technology Process of (+)-1-<(p-tolyl-(R)-sulfinyl)acetyl>-cis-2,3,4,4a(S),5(S),6,7,11c(R)-octahydro-5α(R)-chloro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole

There total 6 articles about (+)-1-<(p-tolyl-(R)-sulfinyl)acetyl>-cis-2,3,4,4a(S),5(S),6,7,11c(R)-octahydro-5α(R)-chloro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 88981-65-1
(R_S)-p-tolylsulfinylacetic acid

: 84960-67-8
cis-2,3,4,4a,5,6,7,11c-octahydro-5α-chloro-7-<(p-methoxyphenyl)-sulfonyl>-1H-pyrido<3,2-c>carbazole

: 88981-66-2,89063-46-7
(+)-1-<(p-tolyl-(R)-sulfinyl)acetyl>-cis-2,3,4,4a(S),5(S),6,7,11c(R)-octahydro-5α(R)-chloro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole

: 88981-66-2
(+)-1-<(p-tolyl-(R)-sulfinyl)acetyl>-cis-2,3,4,4a(R),5(R),6,7,11c(S)-octahydro-5α(R)-chloro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole

Guidance literature:: With N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; In dichloromethane; at 25 ℃; for 12h;
DOI:10.1021/ja00319a034

Reference yield:

: 1519-39-7
(R)-methyl p-tolyl sulfoxide

: 88981-66-2,89063-46-7
(+)-1-<(p-tolyl-(R)-sulfinyl)acetyl>-cis-2,3,4,4a(S),5(S),6,7,11c(R)-octahydro-5α(R)-chloro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, 0 deg C, 0.25 h; 2.) 1 h

2: 47 percent / 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate / CH₂Cl₂ / 12 h / 25 °C

With N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; lithium diisopropyl amide; In dichloromethane;
DOI:10.1021/ja00319a034

Reference yield:

: 1517-82-4
(1R,2S,5R,SS)-(-)-menthyl p-toluenesulfinate

: 88981-66-2,89063-46-7
(+)-1-<(p-tolyl-(R)-sulfinyl)acetyl>-cis-2,3,4,4a(S),5(S),6,7,11c(R)-octahydro-5α(R)-chloro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole

Guidance literature:: Multi-step reaction with 3 steps

2: 1.) LDA / 1.) THF, 0 deg C, 0.25 h; 2.) 1 h

3: 47 percent / 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate / CH₂Cl₂ / 12 h / 25 °C

With N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; lithium diisopropyl amide; In dichloromethane;
DOI:10.1021/ja00319a034