(S)-2-(3,3-difluoro-2-phenylpropyl)isoindoline-1,3-dione

Base Information

Chemical Name:(S)-2-(3,3-difluoro-2-phenylpropyl)isoindoline-1,3-dione
CAS No.:1277102-34-7
Molecular Formula:C₁₇H₁₃F₂NO₂
Molecular Weight:301.293
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-(3,3-difluoro-2-phenylpropyl)isoindoline-1,3-dione

Chemical Property:

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Technology Process of (S)-2-(3,3-difluoro-2-phenylpropyl)isoindoline-1,3-dione

There total 5 articles about (S)-2-(3,3-difluoro-2-phenylpropyl)isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1277102-27-8
C₁₇H₁₄FNO₃

: 1277102-34-7
(S)-2-(3,3-difluoro-2-phenylpropyl)isoindoline-1,3-dione

: 1277102-28-9
2-((2R,3R)-2,3-difluoro-3-phenylpropyl)isoindoline-1,3-dione

Guidance literature:: With (bis-(2-methoxyethyl)amino)sulfur trufluoride; at 70 ℃; Inert atmosphere;
DOI:10.1002/chem.201003320

Reference yield:

: C₁₇H₁₃NO₅S

: 1277102-34-7
(S)-2-(3,3-difluoro-2-phenylpropyl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 4 steps

1: sodium periodate; ruthenium(III) trichloride hydrate / dichloromethane; water; acetonitrile / 0.08 h / 0 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran; acetonitrile / 1 h / 0 °C / Molecular sieve; Inert atmosphere

3: sulfuric acid / tetrahydrofuran; water / 20 °C / Inert atmosphere

4: (bis-(2-methoxyethyl)amino)sulfur trufluoride / 70 °C / Inert atmosphere

With sodium periodate; ruthenium(III) trichloride hydrate; sulfuric acid; tetrabutyl ammonium fluoride; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1002/chem.201003320

Reference yield:

: 1277102-25-6
C₁₇H₁₅NO₄

: 1277102-34-7
(S)-2-(3,3-difluoro-2-phenylpropyl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine; thionyl chloride / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2: sodium periodate; ruthenium(III) trichloride hydrate / dichloromethane; water; acetonitrile / 0.08 h / 0 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran; acetonitrile / 1 h / 0 °C / Molecular sieve; Inert atmosphere

4: sulfuric acid / tetrahydrofuran; water / 20 °C / Inert atmosphere

5: (bis-(2-methoxyethyl)amino)sulfur trufluoride / 70 °C / Inert atmosphere

With pyridine; sodium periodate; thionyl chloride; ruthenium(III) trichloride hydrate; sulfuric acid; tetrabutyl ammonium fluoride; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1002/chem.201003320