(1S,2R)-1-(3,4-dichlorophenyl)-2-hydroxymethylcyclopropanecarboxylic acid (4-fluorobenzyl)methylamide

Base Information

Chemical Name:(1S,2R)-1-(3,4-dichlorophenyl)-2-hydroxymethylcyclopropanecarboxylic acid (4-fluorobenzyl)methylamide
CAS No.:846060-70-6
Molecular Formula:C₁₉H₁₈Cl₂FNO₂
Molecular Weight:382.262
Hs Code.:

Synonyms:

Suppliers and Price of (1S,2R)-1-(3,4-dichlorophenyl)-2-hydroxymethylcyclopropanecarboxylic acid (4-fluorobenzyl)methylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2R)-1-(3,4-dichlorophenyl)-2-hydroxymethylcyclopropanecarboxylic acid (4-fluorobenzyl)methylamide

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

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Technology Process of (1S,2R)-1-(3,4-dichlorophenyl)-2-hydroxymethylcyclopropanecarboxylic acid (4-fluorobenzyl)methylamide

There total 5 articles about (1S,2R)-1-(3,4-dichlorophenyl)-2-hydroxymethylcyclopropanecarboxylic acid (4-fluorobenzyl)methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (+/-)-1-(3,4-dichlorophenyl)-3-oxa-bicyclo[3.1.0]hexan-2-one

: 846060-70-6
(1S,2R)-1-(3,4-dichlorophenyl)-2-hydroxymethylcyclopropanecarboxylic acid (4-fluorobenzyl)methylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: aluminum (III) chloride / 1,2-dichloro-ethane

2.1: sulfuric acid

3.1: aluminum (III) chloride / 1,2-dichloro-ethane / 0.5 h

3.2: 1 h

With aluminum (III) chloride; sulfuric acid; In 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2010.12.135

Reference yield:

: C₁₁H₈Cl₂N₂O₂

: 846060-70-6
(1S,2R)-1-(3,4-dichlorophenyl)-2-hydroxymethylcyclopropanecarboxylic acid (4-fluorobenzyl)methylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: rhodium (II) octanoate dimer / dichloromethane / 4 h / 20 °C

2.1: aluminum (III) chloride / 1,2-dichloro-ethane / 0.5 h

2.2: 1 h

With aluminum (III) chloride; rhodium (II) octanoate dimer; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2010.12.135

Reference yield:

: 1280478-81-0
C₁₉H₁₉Cl₂NO₂

: 846060-70-6
(1S,2R)-1-(3,4-dichlorophenyl)-2-hydroxymethylcyclopropanecarboxylic acid (4-fluorobenzyl)methylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sulfuric acid

2.1: aluminum (III) chloride / 1,2-dichloro-ethane / 0.5 h

2.2: 1 h

With aluminum (III) chloride; sulfuric acid; In 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2010.12.135