Phosphorochloridous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-(2-cyano-ethoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Base Information

Chemical Name:Phosphorochloridous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-(2-cyano-ethoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester
CAS No.:130954-67-5
Molecular Formula:C₄₁H₄₃ClN₇O₈P
Molecular Weight:828.261
Hs Code.:

Phosphorochloridous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-(2-cyano-ethoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

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Chemical Property of Phosphorochloridous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-(2-cyano-ethoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

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Technology Process of Phosphorochloridous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-(2-cyano-ethoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

There total 1 articles about Phosphorochloridous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-(2-cyano-ethoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 130954-59-5
2-cyanoethyl 5'-O-dimethoxytrityl-N²-isobutyryl-O⁶-(2-cyanoethyl)deoxyguanosin-3'-yl phosphonate

: 130954-67-5
Phosphorochloridous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-(2-cyano-ethoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: With pyridine; perdeuteriopyridine; tris(2,4,6-tribromo-phenoxy)dichlorophosphorane; for 0.0833333h;
DOI:10.1021/jo00003a056

Reference yield:

: 130954-67-5
Phosphorochloridous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-(2-cyano-ethoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

: 130954-79-9
C₄₁H₄₃N₇O₁₀P^(1-)

Guidance literature:: With water; iodine; In pyridine; perdeuteriopyridine; for 0.166667h;
DOI:10.1021/jo00003a056

Reference yield:

: 130954-67-5
Phosphorochloridous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-(2-cyano-ethoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

: 130983-97-0
C₆₅H₆₄N₉O₁₆P

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine, pyridine-d5 / 0.08 h

2: I₂-H₂O / pyridine; pyridine-d5 / 0.17 h

With pyridine; perdeuteriopyridine; water; iodine; In pyridine; perdeuteriopyridine;
DOI:10.1021/jo00003a056