Technology Process of Acetamide,
2,2,2-trifluoro-N-[2-[6-methoxy-4-(phenylmethoxy)-1H-indol-3-yl]ethyl]-
There total 12 articles about Acetamide,
2,2,2-trifluoro-N-[2-[6-methoxy-4-(phenylmethoxy)-1H-indol-3-yl]ethyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: acetic acid / CH2Cl2 / 2 h / Ambient temperature
2: 1.) iodomethane / 1.) THF, from 0 deg C to 4 deg C, 30 h, 2.) water, 80 deg C, 3.5 h
3: H2, NH3 / Raney nickel / ethanol / 48 h / 2508 Torr / Ambient temperature
4: 1.) NaOMe / 1.) methanol, 0 deg C, 1 h, 2.) methanol, RT, 1.5 h
With
ammonia; hydrogen; sodium methylate; acetic acid; methyl iodide;
nickel;
In
ethanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) iodomethane / 1.) THF, from 0 deg C to 4 deg C, 30 h, 2.) water, 80 deg C, 3.5 h
2: H2, NH3 / Raney nickel / ethanol / 48 h / 2508 Torr / Ambient temperature
3: 1.) NaOMe / 1.) methanol, 0 deg C, 1 h, 2.) methanol, RT, 1.5 h
With
ammonia; hydrogen; sodium methylate; methyl iodide;
nickel;
In
ethanol;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: H2, NH3 / Raney nickel / ethanol / 48 h / 2508 Torr / Ambient temperature
2: 1.) NaOMe / 1.) methanol, 0 deg C, 1 h, 2.) methanol, RT, 1.5 h
With
ammonia; hydrogen; sodium methylate;
nickel;
In
ethanol;
